High-throughput screening to identify potential inhibitors of the Zα domain of the adenosine deaminase 1 (ADAR1)
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.06.080
Abstract: Adenosine deaminases acting on RNA 1 (ADAR1) are enzymes involved in editing adenosine to inosine in the dsRNAs of cells associated with cancer development. The p150 isoform of ADAR1 is the only isoform containing the… read more here.
Keywords: adar1; potential inhibitors; throughput screening; identify potential ... See more keywords
RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01458-8
Abstract: Adenosine deaminase acting on RNA 1 (ADAR1) is the master RNA editor, catalyzing the deamination of adenosine to inosine. RNA editing is vital for preventing abnormal activation of cytosolic nucleic acid sensing pathways by self-double-stranded… read more here.
Keywords: rna secondary; adar1; rna; secondary structure ... See more keywords
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0768-9
Abstract: Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the… read more here.
Keywords: checkpoint blockade; resistance; overcomes resistance; adar1 ... See more keywords
Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA editing enzyme Adar1 is required for fear extinction
Sign Up to like & getrecommendations! Published in 2020 at "Nature neuroscience"
DOI: 10.1038/s41593-020-0627-5
Abstract: DNA forms conformational states beyond the right-handed double helix; however, the functional relevance of these noncanonical structures in the brain remains unknown. Here we show that, in the prefrontal cortex of mice, the formation of… read more here.
Keywords: adar1; dna; extinction; regulation ... See more keywords
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13580-0
Abstract: ADAR1-dependent A-to-I editing has recently been recognized as a key process for marking dsRNA as self, therefore, preventing innate immune activation and affecting the development and resolution of immune-mediated diseases and infections. Here, we have… read more here.
Keywords: adar1; adar1 knockdown; immune activation; innate immune ... See more keywords
ADAR1 affects gastric cancer cell metastasis and reverses cisplatin resistance through AZIN1.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001516
Abstract: Adenosine deaminases acting on RNA1 (ADAR1) are involved in the occurrence and development of cancers. Although the role of ADAR1 in gastric cancer metastasis has been reported, the role of ADAR1 in the mechanism of… read more here.
Keywords: cancer cells; adar1; expression; gastric cancer ... See more keywords
ADAR1 Biology Can Hinder Effective Antiviral RNA Interference
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00245-23
Abstract: All life at the cellular level has the capacity to induce an antiviral response. Here, we examine the result of imposing the antiviral response of one branch of life onto another and find evidence for… read more here.
Keywords: rnai; rna; adar1; life ... See more keywords
BS8 Essential role of endothelial ADAR1 RNA editing in vascular integrity
Sign Up to like & getrecommendations! Published in 2019 at "Heart"
DOI: 10.1136/heartjnl-2019-bcs.172
Abstract: Introduction RNA editing is the binding to double-stranded RNA (dsRNA) of the adenosine deaminase acting on RNA (ADAR) family to catalyse the deamination of adenosine (A)-to- inosine (I). We have recently reported that ADAR1 is… read more here.
Keywords: role; rna editing; adar1; endothelial adar1 ... See more keywords
Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004666
Abstract: Background Despite the success of HER2-targeted therapy in achieving prolonged survival in approximately 50% of treated individuals, treatment resistance is still an important challenge for HER2+ breast cancer (BC) patients. The influence of both adaptive… read more here.
Keywords: her2; therapy; adar1; resistance ... See more keywords
Abstract 1704: Interferon inducible ADAR1 is essential for the survival of oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1704
Abstract: Treating oral squamous cell carcinoma (OSCC) remains challenging due to limited knowledge of the critical genes that could affect cell survival in OSCC. We have previously utilized genome-wide CRISPR-Cas9 knockout functional screens to explore the… read more here.
Keywords: cell carcinoma; cell; squamous cell; adar1 ... See more keywords
Abstract A45: Loss of Adar1 in pancreatic acinar cells leads to cell apoptosis and inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.panca19-a45
Abstract: While genetic mutations have been shown to drive pancreatic ductal adenocarcinoma (PDAC), epigenomic alterations in cancer cells may also contribute to tumor initiation and progression. Adenosine-to-inosine (A-to-I) editing is the most common type of RNA… read more here.
Keywords: lsl yfp; loss; cancer; adar1 ... See more keywords