Target-responsive subcellular catabolism analysis for early-stage antibody‒drug conjugates screening and assessment
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DOI: 10.1016/j.apsb.2021.05.024
Abstract: Abstract Events including antibody‒antigen affinity, internalization, trafficking and lysosomal proteolysis combinatorially determine the efficiency of antibody‒drug conjugate (ADC) catabolism and hence the toxicity. Nevertheless, an approach that conveniently identifies proteins requisite for payload release and… read more here.
Keywords: catabolism; adc catabolism; responsive subcellular; subcellular catabolism ... See more keywords