A Simple and Efficient Method to Generate Dual Site-Specific Conjugation ADCs with Cysteine Residue and an Unnatural Amino Acid.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00134
Abstract: Antibody-drug conjugates (ADCs) are complex pharmaceutical molecules that combine monoclonal antibodies with biologically active drugs through chemical linkers. ADCs are designed to specifically kill disease cells by utilizing the target specificity of antibodies and the… read more here.
Keywords: efficient method; cysteine; adcs; method ... See more keywords
Massive MIMO With Ternary ADCs
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Signal Processing Letters"
DOI: 10.1109/lsp.2020.2967997
Abstract: Massive multiple-input-multiple-output (MIMO) system inevitably faces the hardware cost and energy efficiency problem due to its large number of antennas at the base station (BS). The use of low-resolution analog-to-digital converters (ADCs), e.g., typical 1-bit… read more here.
Keywords: adcs; bit adcs; massive mimo; ternary adcs ... See more keywords
A 28-nm 9T1C SRAM-Based CIM Macro With Hierarchical Capacitance Weighting and Two-Step Capacitive Comparison ADCs for CNNs
Sign Up to like & getrecommendations! Published in 2025 at "IEEE Transactions on Very Large Scale Integration (VLSI) Systems"
DOI: 10.1109/tvlsi.2025.3545635
Abstract: In the realm of charge-domain computing-in-memory (CIM) macros, reducing the area of capacitor ladder and analog-to-digital converter (ADC) while maintaining high throughput remains a significant challenge. This brief introduces an adjustable-weight CIM macro designed to… read more here.
Keywords: efficiency; area; cim macro; adcs ... See more keywords
Joint Beamforming Design and Bit Allocation in Massive MIMO With Resolution-Adaptive ADCs
Sign Up to like & getrecommendations! Published in 2025 at "IEEE Transactions on Wireless Communications"
DOI: 10.1109/twc.2025.3568590
Abstract: Low-resolution analog-to-digital converters (ADCs) have emerged as a promising technology for reducing power consumption and complexity in massive multiple-input multiple-output (MIMO) systems while maintaining satisfactory spectral and energy efficiencies (SE/EE). In this work, we first… read more here.
Keywords: resolution adaptive; adcs; resolution; bit allocation ... See more keywords
Histological classification of uterine cervical adenocarcinomas: Its alteration and current status
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.16287
Abstract: Adenocarcinomas (ADCs) of the uterine cervix are relatively minor compared to squamous cell carcinomas. However, ADCs are histologically and histogenetically unique, especially because they can be with or without human papillomavirus (HPV) infection. At present,… read more here.
Keywords: classification; hpv; ais; adcs ... See more keywords
The potential significance of alpha‐enolase (ENO1) in lung adenocarcinomas – A utility of the immunohistochemical expression in pathologic diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "Pathology International"
DOI: 10.1111/pin.12607
Abstract: We herein analyzed the relationships among the immunohistochemical expression of alpha‐enolase (ENO1) and clinicopathological factors in order to define the significance of ENO1 in lung adenocarcinomas (ADCs). ENO1 expression was detected in most of the… read more here.
Keywords: enolase eno1; adcs; eno1; expression ... See more keywords
Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004646
Abstract: Background Both ganglioside GD2-targeted immunotherapy and antibody-drug conjugates (ADCs) have demonstrated clinical success as solid tumor therapies in recent years, yet no research has been carried out to develop anti-GD2 ADCs against solid tumors. This… read more here.
Keywords: gd2; drug conjugates; adcs; antibody drug ... See more keywords
Abstract 2186: Peptide-cleavable maytansinoid (ADCs) induce high bystander killing leading to improved anti-tumor activityin vivo
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2186
Abstract: Antibodies targeting surface antigens on cancer cells typically have progressively lower access to tumor cells that are further removed from blood vessels. Also, the antibody will not bind to cells in the tumor mass that… read more here.
Keywords: adcs; maytansinoid adcs; cancer; bystander ... See more keywords
Abstract 982: Development of homogeneous dual-drug ADCs: Application to the co-delivery of auristatin payloads with complementary antitumor activities
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-982
Abstract: A common theme in treating cancer is the use of combination chemotherapy, where multiple drugs with different mechanisms of action are combined to elicit synergistic activity or overcome differential drug sensitivities. Antibody-drug conjugates (ADCs) have… read more here.
Keywords: auristatin; delivery; adcs; drug ... See more keywords
Abstract 737: Antibody drug conjugates with anthracycline payload induce tumor-selective antitumor immunity and exhibit a favorable safety profile in cynomolgus monkey toxicology studies
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-737
Abstract: Background: Antibody Drug Conjugates (ADCs) target highly potent small molecule cytotoxic agents to tumors via tumor-specific antibodies. The therapeutic index of these drugs is strongly affected by a multitude of parameters, including -most importantly- (i)… read more here.
Keywords: immunity; adcs; antibody drug; toxicology ... See more keywords
Abstract 746: Development of novel formats of anti-AXL ADCs
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-746
Abstract: AXL is a member of the Tyro3- AXL -Mer (TAM) receptor tyrosine kinase subfamily which has been associated with several cellular functions including growth, migration, aggregation, and anti-inflammation (Li Y et al., 2009) via activation… read more here.
Keywords: axl; anti axl; adcs; cancer ... See more keywords