Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour
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DOI: 10.1038/ncomms15527
Abstract: Liability to develop drug addiction is heritable, but the precise contribution of non-Mendelian factors is not well understood. Here we separate male rats into addiction-like and non-addiction-like groups, based on their incentive motivation to seek… read more here.
Keywords: male rats; addiction like; drug; cocaine ... See more keywords
Compulsive‐like eating of high‐fat high‐sugar food is associated with ‘addiction‐like’ glutamatergic dysfunction in obesity prone rats
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DOI: 10.1111/adb.13206
Abstract: Chronic overeating is a core feature of diet‐induced obesity. There is increasing evidence that in vulnerable individuals, such overeating could become compulsive, resembling an addictive disorder. The transition to compulsive substance use has been linked… read more here.
Keywords: addiction like; diet induced; compulsive like; addiction ... See more keywords
Neural and behavioral correlates of sexual stimuli anticipation point to addiction-like mechanisms in compulsive sexual behavior disorder
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Behavioral Addictions"
DOI: 10.1556/2006.2022.00035
Abstract: Abstract Background and aims Compulsive sexual behavior disorder (CSBD) is characterized by persistent patterns of failure to control sexual impulses resulting in repetitive sexual behavior, pursued despite adverse consequences. Despite previous indications of addiction-like mechanisms… read more here.
Keywords: anticipation; addiction like; like mechanisms; sexual behavior ... See more keywords
Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.832899
Abstract: Cocaine affects food intake, metabolism and bodyweight. It has been hypothesized that feeding hormones like leptin play a role in this process. Preclinical studies have shown a mutually inhibitory relationship between leptin and cocaine, with… read more here.
Keywords: blood leptin; addiction like; cocaine;
Fetal Programming by Methyl Donors Modulates Central Inflammation and Prevents Food Addiction-Like Behavior in Rats
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DOI: 10.3389/fnins.2020.00452
Abstract: Fetal programming by hypercaloric intake leads to food addiction-like behavior and brain pro-inflammatory gene expression in offspring. The role of methylome modulation during programming on central immune activation and addiction-like behavior has not been characterized.… read more here.
Keywords: addiction like; food addiction; like behavior; fetal programming ... See more keywords
Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1135929
Abstract: Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-administration (SA) responses in normal rodent models, despite seemingly inducing addiction-like effects in humans. Thus, an efficient pre-clinical model must be developed to determine cannabinoid abuse potential… read more here.
Keywords: addiction like; jwh 018; cryab; cryab mice ... See more keywords
Addiction-like Eating in Chinese Adults: An Assessment Tool and Its Associations with Modern Eating-Related Habits
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DOI: 10.3390/nu14224836
Abstract: Objectives: The rapid increase in Chinese obesity rates has aroused research interest in addiction-like eating (AE); however, the unavailability of assessment tools is a major barrier to further investigation. To address the research gap, this… read more here.
Keywords: addiction like; chinese adults; modern eating; related habits ... See more keywords
Disordered Eating Behaviors Related to Food Addiction/Eating Addiction in Inpatients with Obesity and the General Population: The Italian Version of the Addiction-like Eating Behaviors Scale (AEBS-IT)
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DOI: 10.3390/nu15010104
Abstract: Purpose. The purpose of this research is to test the psychometric properties and factorial structure of the Addiction-like Eating Behaviors Scale (AEBS) in an Italian sample of adults with severe obesity seeking treatment for weight… read more here.
Keywords: addiction like; general population; eating behaviors; addiction ... See more keywords