Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia.
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DOI: 10.1158/2643-3230.bcd-21-0026
Abstract: In this issue of Blood Cancer Discovery, Yan and colleagues discovered that mitochondrial deacylase, SIRT5, is required in AML cells to support mitochondrial oxidative phosphorylation, maintain redox homeostasis, and drive glutaminolysis. The new SIRT5 inhibitor,… read more here.
Keywords: myeloid leukemia; acute myeloid; oncogene addiction; addiction sirt5 ... See more keywords