Addition of HO‐Acids to N,N‐Bis(oxy)enamines: Mechanism, Scope and Application to the Synthesis of Pharmaceuticals
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DOI: 10.1002/ejoc.201701266
Abstract: The regioselectivity of the addition of HO-acids to the activated π bond in N,N-bis(oxy)enamines has been found to be dramatically dependent upon the solvent. Mechanistic investigations and quantum-chemical calculations revealed that solvent affects the reaction… read more here.
Keywords: bis oxy; enamines mechanism; addition acids; oxy enamines ... See more keywords