Enantioselective Terminal Addition to Allenes by Dual Chiral Primary Amine/Palladium Catalysis.
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DOI: 10.1021/jacs.7b00437
Abstract: We herein describe a synergistic chiral primary amine/achiral palladium catalyzed enantioselective terminal addition to allenes with α-branched β-ketocarbonyls and aldehydes. The reactions afford allylic adducts bearing acyclic all-carbon quaternary centers with high regio- and enantioselectivity.… read more here.
Keywords: enantioselective terminal; terminal addition; palladium; addition allenes ... See more keywords