Practical procedure for a theoretical investigation of thermodynamics and kinetics aspects of different-scale radical reactions from addition and cyclization to cyclocopolymerization involving maleic anhydride and divinyl ether
Sign Up to like & getrecommendations! Published in 2018 at "Polymer"
DOI: 10.1016/j.polymer.2018.05.032
Abstract: Abstract Quantum chemical techniques reasonable in practical simulation of carbon-centered radical reactions were evaluated scaling up from addition and cyclization of small radicals to growing chains in homo-, cross- and cyclo-polymerization. The methods preselected via… read more here.
Keywords: maleic anhydride; radical reactions; thermodynamics; cyclization ... See more keywords
Palladium-Catalyzed Addition/Cyclization of (2-Hydroxyaryl)boronic Acids with Alkynylphosphonates: Access to Phosphacoumarins.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03151
Abstract: A facile palladium-catalyzed addition/cyclization of (2-hydroxyaryl)boronic acids with alkynylphosphonates has been developed, providing an effective strategy to construct a series of valuable phosphacoumarins. This methodology features excellent regioselectivity and broad substrate tolerance. read more here.
Keywords: cyclization hydroxyaryl; boronic acids; catalyzed addition; palladium catalyzed ... See more keywords
Construction of N-Polyheterocycles by N-Heterocyclic Carbene Catalysis via a Regioselective Intramolecular Radical Addition/Cyclization Cascade.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01729
Abstract: N-Polyheterocycles are rapidly accessed by N-heterocyclic carbene (NHC) catalysis through regioselective sequential radical addition/cyclization in the absence of any metals or oxidants. The transformation occurs under mild conditions and enjoys a wide substrate scope with… read more here.
Keywords: catalysis; addition cyclization; radical addition; heterocyclic carbene ... See more keywords
Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles.
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DOI: 10.1021/acs.orglett.6b03499
Abstract: The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally diverse isoquinolines and isoquinolones.… read more here.
Keywords: isoquinolines isoquinolones; addition; tandem addition; addition cyclization ... See more keywords
A dienamine-mediated deconjugative addition/cyclization cascade of γ,γ-disubstituted enals with carboxylic acid-activated enones: a rapid access to highly functionalized γ-lactones
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01367a
Abstract: An aminocatalytic deconjugative addition/cyclization cascade of γ,γ-disubstituted enals with carboxylic acid-activated enones was realized. The in situ generated dienamine species was regioselectively trapped at the α position by carboxylic acid-activated enones, leading to highly functionalized… read more here.
Keywords: activated enones; cyclization cascade; carboxylic acid; acid activated ... See more keywords
Asymmetric Organocatalytic Michael Addition–Cyclization Cascade of Cyclopentane-1,2-dione with Substituted α,β-Unsaturated Aldehydes
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DOI: 10.1055/s-0036-1588787
Abstract: An asymmetric organocatalytic Michael addition–cyclization cascade reaction has been developed using cyclopentane-1,2-dione as a Michael donor and α,β-unsaturated aldehydes as Michael acceptors. Bicyclic hemiacetals were obtained in excellent yields and enantioselectivities. On the basis of… read more here.
Keywords: michael; cyclopentane; michael addition; organocatalytic michael ... See more keywords
DBU Promoted Polysubstituted Arene Formation via a Michael Addition/Cyclization/Elimination Cascade Reaction
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DOI: 10.3390/molecules27238167
Abstract: The straightforward construction of polysubstituted arenes is essential in both synthetic chemistry and medicinal chemistry. Herein, we reported a DBU promoted Michael addition/cyclization/elimination cascade reaction between vinylogous malononitrile derivatives and chlorinated nitrostyrenes for the synthesis… read more here.
Keywords: reaction; cascade; chemistry; michael addition ... See more keywords
Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
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DOI: 10.3390/molecules28031145
Abstract: Radical reactions are powerful in creating carbon–carbon and carbon–heteroatom bonds. Designing one-pot radical reactions with cascade transformations to assemble the cyclic skeletons with two new functional groups is both synthetically and operationally efficient. Summarized in… read more here.
Keywords: difunctionalization dienes; addition cyclization; dienes enynes; radical addition ... See more keywords