Addition-Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03361
Abstract: Dynamic information of intracellular transcripts is essential to understand their functional roles. Routine RNA-sequencing (RNA-seq) methods only measure RNA species at a steady state and do not provide RNA dynamic information. Here, we develop addition-elimination… read more here.
Keywords: rna dynamics; addition elimination; chemistry; transition ... See more keywords
Reaction of 2,5-dihydroxy-[1,4]-benzoquinone with nucleophiles - ipso-substitution vs. addition/elimination.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04748a
Abstract: 2,5-Dihydroxy-[1,4]-benzoquinone (DHBQ) reacts readily with secondary amines to 2,5-diamino compounds and with thiols to the corresponding 2,5-dithioether derivatives. The literature has been inconclusive about the detailed mechanism, as both ipso-substitution at C-2/C-5 and the sequence… read more here.
Keywords: addition elimination; reaction; ipso substitution;
Radical Allylation: E-Selective Radical Conjugate Addition–Elimination Reaction from Morita–Baylis–Hillman Adducts
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DOI: 10.1055/s-0036-1590922
Abstract: Triethylborane-mediated radical allylation was performed from Morita–Baylis–Hillman alcohols with no need of protecting group. The radical conjugated addition–elimination reaction is highly selective, and trisubstituted E-alkenes were obtained. This reaction opened a new route for the… read more here.
Keywords: morita baylis; radical allylation; baylis hillman; addition elimination ... See more keywords
Addition-elimination of nitroalkanes to 3-phenacylideneoxindoles—direct method for the synthesis of 3-alkenylphenacylidene-oxindoles
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1587779
Abstract: Abstract The first addition-elimination of nitroalkanes to 3-phenacylideneoxindoles was developed, affording the corresponding 3-alkenylphenacylidene-oxindoles with high yields.The addition-elimination mechanism of 3-phenacylideneoxindoles with nitroalkanes and removable NO2 group in concert guarantees the high regioselectivity. GRAPHICAL ABSTRACT read more here.
Keywords: addition; nitroalkanes phenacylideneoxindoles; addition elimination; alkenylphenacylidene oxindoles ... See more keywords
Feed based trajectory addition and elimination algorithm combined with stochastic meshless modelling to simulate roughness in surface grinding
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering"
DOI: 10.1177/09544089221107596
Abstract: Surface grinding is observed to be an inevitable machining event in many of the functional engineering surfaces after pre-processing stages such as milling. Prediction of roughness profile after grinding on such initial surfaces, for selected… read more here.
Keywords: addition elimination; trajectory addition; surface; surface grinding ... See more keywords