Rhodium(III)-Catalyzed Asymmetric Addition of Inert Arene C-H Bond to Aldehydes To Afford Enantioenriched Phthalides.
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DOI: 10.1021/acs.orglett.0c01052
Abstract: An asymmetric rhodium(III)-catalyzed Grignard-type addition of inert arene C-H bond to aldehydes is reported. It provides a new strategy for the synthesis of chiral 3-substituted phthalides in good yields (up to 87%) with high enantiomeric… read more here.
Keywords: addition inert; addition; iii catalyzed; arene bond ... See more keywords