Total Synthesis of a PPAP, Nemorosonol, Using a Tandem Michael Addition-Intramolecular Aldol Reaction.
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DOI: 10.1021/acs.orglett.2c01745
Abstract: A strategy for constructing a tricyclo[4.3.1.03,7]decane skeleton, which is common to many polycyclic polyprenylated acylphloroglucinols, has been established. The key step was a tandem Michael addition-intramolecular aldol reaction with 3-ethoxy-1-phenyl-2-proyn-1-one, which affords a tricyclo[4.3.1.03,7]decane skeleton… read more here.
Keywords: addition intramolecular; michael addition; aldol reaction; intramolecular aldol ... See more keywords