Isothiourea-Catalyzed Enantioselective Michael Addition of Malonates to α,β-Unsaturated Aryl Esters
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DOI: 10.1021/acs.orglett.2c01486
Abstract: An enantioselective Michael addition of malonates to α,β-unsaturated para-nitrophenyl esters was achieved using the Lewis basic isothiourea HyperBTM, giving excellent levels of product enantioselectivity (up to >99:1 enantiomeric ratio) in good yields and with complete… read more here.
Keywords: addition malonates; malonates unsaturated; michael addition; enantioselective michael ... See more keywords
Enantioselective Organocatalytic Conjugate Addition of Malonates to β,β-Disubstituted β-Trifluoromethyl Enones under High Pressure
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DOI: 10.1021/acs.orglett.5c00065
Abstract: The first enantioselective Michael addition of malonates to acyclic β,β-disubstituted enones has been developed. Sterically hindered β-trifluoromethyl α,β-unsaturated 2-acyl thiazoles and benzothiazoles were found to be the most reactive groups of enones in the reaction… read more here.
Keywords: enantioselective organocatalytic; addition malonates; malonates disubstituted; addition ... See more keywords