Cascade Grignard Addition: Propargyl Claisen Rearrangement for the Stereoselective Synthesis of α‑Allene Quaternary Centers in Cyclohexanones
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DOI: 10.1021/acs.orglett.5c02006
Abstract: We report a new method for the enantio- and diastereoselective synthesis of α-allene quaternary centers in fully substituted cyclohexanones at the α-positions. This reaction involves asymmetric 1,2-carbonyl addition to 2-O-propargyl enones using a mixture of… read more here.
Keywords: addition propargyl; synthesis allene; allene quaternary; propargyl claisen ... See more keywords