Organocatalytic Cascade Knoevenagel–Michael Addition Reactions: Direct Synthesis of Polysubstituted 2-Amino-4H-Chromene Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Catalysis Letters"
DOI: 10.1007/s10562-019-03089-8
Abstract: In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41… read more here.
Keywords: synthesis polysubstituted; michael addition; polysubstituted amino; addition reactions ... See more keywords
Discovery of chiral N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113583
Abstract: Herein we disclosed the novel nucleophilic addition reactions of the thiophenols and oxazolinium (DCZ0358) to produce N-2'-aryletheryl-1'-alkoxy-ethyl substituted arylisoquinolones. After evaluating the anti-inflammatory activity in vitro, 2d was found having significant anti-TNFα activity. Through the amplified… read more here.
Keywords: anti inflammatory; thiophenols oxazolinium; reactions thiophenols; nucleophilic addition ... See more keywords
Supported iron catalysts for Michael addition reactions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2017.12.029
Abstract: Abstract Heterogeneous catalysts have been widely used for chemical transformations and offer easy product separation in addition to their high activity. Iron is an earth-abundant metal, but it has not been studied thoroughly as heterogeneous… read more here.
Keywords: supported iron; iron catalysts; michael addition; iron ... See more keywords
Boron-Heteroatom Addition Reactions via Borylative Heterocyclization: Oxyboration, Aminoboration, and Thioboration.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.7b00365
Abstract: Organoboron compounds and heterocycles are powerful building blocks and precursors for organic synthesis, including for drug discovery and agrochemical and material synthesis. The common strategy for the synthesis of borylated heterocycles involves two separate synthetic… read more here.
Keywords: borylation; bond; addition reactions; boron ... See more keywords
Catalytic Asymmetric Addition Reactions of Formaldehyde N,N-Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01857
Abstract: A number of nitrile-containing chiral molecules were synthesized via asymmetric nucleophilic addition of formaldehyde N,N-dialkylhydrazone as the nitrile equivalent. Chiral N,N'-dioxide/metal salt complexes enabled the asymmetric addition reactions to both isatin-derived imines and α,β-unsaturated ketones,… read more here.
Keywords: formaldehyde dialkylhydrazone; addition; asymmetric addition; addition reactions ... See more keywords
Models for Cooperative Catalysis: Oxidative Addition Reactions of Dimethylplatinum(II) Complexes with Ligands Having Both NH and OH Functionality
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b03089
Abstract: The role of NH and OH groups in the oxidative addition reactions of the complexes [PtMe2(κ2-N,N′-L)], L = 2-C5H4NCH2NH-x-C6H4OH [3, x = 2, L = L1; 4, x = 3, L = L2; 5, x… read more here.
Keywords: models cooperative; cooperative catalysis; oxidative addition; addition reactions ... See more keywords
Mechanistic Studies Yield Improved Protocols for Base-Catalyzed Anti-Markovnikov Alcohol Addition Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13397
Abstract: The catalytic anti-Markovnikov addition of alcohols to simple alkenes is a longstanding synthetic challenge. We recently disclosed the use of organic superbase catalysis for the nucleophilic addition of alcohols to activated styrene derivatives. This article… read more here.
Keywords: addition; anti markovnikov; mechanistic studies; addition reactions ... See more keywords
Structural and Electronic Noninnocence of α-Diimine Ligands on Niobium for Reductive C-Cl Bond Activation and Catalytic Radical Addition Reactions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b02710
Abstract: A d0 niobium(V) complex, NbCl3(α-diimine) (1a), supported by a dianionic redox-active N,N'-bis(2,6-diisopropylphenyl)-1,4-diaza-2,3-dimethyl-1,3-butadiene (α-diimine) ligand (ene-diamido ligand) served as a catalyst for radical addition reactions of CCl4 to α-olefins and cyclic alkenes, selectively affording 1:1 radical… read more here.
Keywords: addition; bond; reaction; diimine ... See more keywords
Rhodium-catalyzed asymmetric 1,4-addition reactions of aryl boronic acids with nitroalkenes: reaction mechanism and development of homogeneous and heterogeneous catalysts† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03025h
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc03025h
Abstract: Asymmetric 1,4-additions of arylboronic acids with nitroalkenes catalyzed by rhodium complexes or heterogeneous Rh–Ag bimetallic nanoparticles with a chiral diene ligand bearing a tertiary butyl amide moiety are developed. read more here.
Keywords: catalyzed asymmetric; rhodium; rhodium catalyzed; asymmetric addition ... See more keywords
Recent developments in 1,6-addition reactions of para-quinone methides (p-QMs)
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00387e
Abstract: In recent years, para-quinone methides (p-QMs) have emerged as attractive and versatile synthons in organic synthesis owing to their high reactivity. Consequently, p-QM chemistry has attracted increasing attention and remarkable advances have been achieved. Among… read more here.
Keywords: addition; quinone methides; methides qms; chemistry ... See more keywords
Mechanochemistry and Eco-Bases for Sustainable Michael Addition Reactions
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DOI: 10.3390/molecules27103306
Abstract: The Michael addition reaction was revisited with a full focus on sustainability combined with efficiency, using mechanochemistry in mild conditions. First, the synthesis of cyclopentenone derivatives was chosen as a model reaction to find optimal… read more here.
Keywords: addition reactions; mechanochemistry eco; eco bases; michael addition ... See more keywords