Thiol-based michael-type addition. A systematic evaluation of its controlling factors
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DOI: 10.1016/j.tet.2020.131637
Abstract: Abstract This paper is about the factors controlling kinetics and product stability of this popular bioconjugation reaction. We demonstrate that a) thiol pKa, i.e. the amount of thiolates, is the only determinant of the reaction… read more here.
Keywords: type addition; addition systematic; michael type; reaction ... See more keywords