Copper-Catalyzed Asymmetric Addition of Tertiary Carbon Nucleophiles to 2 H-Azirines: Access to Chiral Aziridines with Vicinal Tetrasubstituted Stereocenters.
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DOI: 10.1021/acs.orglett.8b02274
Abstract: A catalytic asymmetric nucleophilic addition of tertiary carbon nucleophiles to 2 H-azirines was established in the presence of the chiral N,N'-dioxide/CuII complex. Various chiral aziridines with vicinal tetrasubstituted stereocenters were obtained in high yields with… read more here.
Keywords: nucleophiles azirines; carbon nucleophiles; chiral aziridines; tertiary carbon ... See more keywords
Iridium-catalyzed Reductive Nucleophilic Addition to Tertiary Amides
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DOI: 10.1246/cl.190467
Abstract: This article describes the development of an iridium-catalyzed reductive nucleophilic addition to tertiary amides. A conspicuous feature of this reaction is its high amide-selectivity via two proce... read more here.
Keywords: iridium catalyzed; tertiary amides; addition tertiary; reductive nucleophilic ... See more keywords