A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
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DOI: 10.1038/s41467-021-22395-7
Abstract: Streptoseomycin (STM, 1) is a bacterial macrolactone that has a unique 5/14/10/6/6-pentacyclic ring with an ether bridge. We have previously identified the biosynthetic gene cluster for 1 and characterized StmD as [6 + 4]- and [4 + 2]-bispericyclase that… read more here.
Keywords: cycloaddition adduct; adduct; adduct biosynthetic; intermediate streptoseomycin ... See more keywords