Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase
Sign Up to like & getrecommendations! Published in 2025 at "PeerJ"
DOI: 10.7717/peerj.19577
Abstract: Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer. Intriguingly, the… read more here.
Keywords: adducts duplex; thymine dna; thymine; duplex dna ... See more keywords