Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies.
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DOI: 10.4155/fmc-2021-0251
Abstract: Background: Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the lysine histone methyltransferases, DOT1L is implicated in various diseases, making it a very interesting target… read more here.
Keywords: based analog; adenine antidote; mll rearranged; antidote mll ... See more keywords