Nicotinamide adenine dinucleotide metabolism: driving or counterbalancing inflammatory bowel disease?
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14528
Abstract: Nicotinamide adenine dinucleotide (NAD) is an important electron and hydrogen carrier for oxidative metabolism and involved in energy production, antioxidant responses, and signal transduction within cells. NAD‐consuming enzymes can mediate post‐translational modifications, such as deacylation… read more here.
Keywords: metabolism; nicotinamide adenine; adenine dinucleotide; inflammatory bowel ... See more keywords
Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25474
Abstract: Despite decades of epilepsy research, 30% of focal epilepsies remain resistant to antiseizure drugs, with effective drug development impeded by lack of understanding on how seizures are initiated. Here, we report the mechanism of seizure… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; dinucleotide phosphate; phosphate oxidase ... See more keywords
Viewing teratogens through the lens of nicotinamide adenine dinucleotide (NAD+)
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2089
Abstract: Nicotinamide adenine dinucleotide (NAD+) depletion is associated with numerous diseases in humans. Recently it was revealed that genetic blockage of the NAD+ synthesis pathway in humans causes birth defects in multiple organ systems and miscarriage.… read more here.
Keywords: nicotinamide adenine; adenine dinucleotide; lens nicotinamide; viewing teratogens ... See more keywords
Nicotinamide Adenine Dinucleotide Supplementation in Parkinson's Disease: A Potential Disease‐Modifying Agent Targeting Multiple Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13500
Abstract: modi fi cation and neuroprotection are still unmet needs in Parkinson ’ s disease (PD), due to several challenges, including multiple pathogenic the upregulation of genes involved in proteasomal function, mitochondrial homeostasis, and antioxidant function.… read more here.
Keywords: supplementation; nicotinamide adenine; adenine dinucleotide; disease ... See more keywords
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09805-6
Abstract: Nicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a… read more here.
Keywords: adenine dinucleotide; emerges therapeutic; ischemic conditions; nicotinamide adenine ... See more keywords
Ethanol Biofuel Cell Utilizing Photo-Excited Flavin-Mediated Oxidation of β-Nicotinamide Adenine Dinucleotide Hydrate (NADH) at the Anode and Reduction of H+ Ions at the Cathode
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Electronic Materials"
DOI: 10.1007/s11664-020-08189-5
Abstract: At the anode, the electrochemical oxidation of β-nicotinamide adenine dinucleotide hydrate (NADH) to its oxidized form (NAD+) spontaneously proceeded using photo-excited flavin mononucleotide (FMN) as the redox mediator. At the cathode, H+ ions were electroreduced… read more here.
Keywords: adenine dinucleotide; biofuel; nicotinamide adenine; oxidation nicotinamide ... See more keywords
Toward an ideal platform structure based on MgO-templated carbon for flavin adenine dinucleotide-dependent glucose dehydrogenase-Os polymer-hydrogel electrodes
Sign Up to like & getrecommendations! Published in 2020 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2020.136110
Abstract: Abstract For the efficient electrochemical glucose oxidation on the electrode modified with redox hydrogel involving Os-tethered polymer and flavin adenine dinucleotide-dependent glucose dehydrogenase (FADGDH), the effect of pore size of MgO-templated carbon (MgOC) as an… read more here.
Keywords: adenine dinucleotide; carbon; hydrogel; dinucleotide dependent ... See more keywords
Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.10.032
Abstract: Nicotinamide riboside, the most recently discovered form of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be potent supplements boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus preventing or ameliorating metabolic… read more here.
Keywords: milk; adenine dinucleotide; nicotinamide mononucleotide; nicotinamide adenine ... See more keywords
Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107092
Abstract: Nicotinamide adenine dinucleotide (NAD + ) is an essential cofactor in numerous metabolic pathways, and so may support protective and reparative processes against central nervous system diseases such as multiple sclerosis (MS). Here, we investigated the therapeutic… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; treatment; autoimmune encephalomyelitis ... See more keywords
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118156
Abstract: AIMS Flavin adenine dinucleotide (FAD), participates in fatty acid β oxidation as a cofactor, which has been confirmed to enhance SCAD activity and expression. However, the role of FAD on hypertensive vascular remodeling is unclear.… read more here.
Keywords: adenine dinucleotide; dinucleotide ameliorates; hypertensive vascular; flavin adenine ... See more keywords
Discovery of Nicotinamide Adenine Dinucleotide Binding Proteins in the Escherichia coli Proteome Using a Combined Energetic- and Structural-Bioinformatics-Based Approach.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00624
Abstract: Protein-ligand interaction plays a critical role in regulating the biochemical functions of proteins. Discovering protein targets for ligands is vital to new drug development. Here, we present a strategy that combines experimental and computational approaches… read more here.
Keywords: adenine dinucleotide; proteins escherichia; nicotinamide adenine; binding proteins ... See more keywords