Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17047-1
Abstract: Recombinant adeno-associated viruses (rAAVs) are currently considered the safest and most reliable gene delivery vehicles for human gene therapy. Three serotype capsids, AAV1, AAV2, and AAV9, have been approved for commercial use in patients, but… read more here.
Keywords: novel; gene therapy; adeno associated; adeno ... See more keywords
Rational engineering of adeno‐associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13339
Abstract: Gene therapy based on recombinant adeno‐associated viral (rAAV) vectors has been proved to be clinically effective for genetic diseases. However, there are still some limitations, including possible safety concerns for high dose delivery and a… read more here.
Keywords: adeno; rational engineering; associated virus; adeno associated ... See more keywords