Minimally invasive determination of pancreatic ductal adenocarcinoma (PDAC) subtype by means of circulating cell‐free RNA
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13747
Abstract: Pancreatic ductal adenocarcinoma (PDAC) comprises two clinically relevant molecular subtypes that are currently determined using tissue biopsies, which are spatially biased and highly invasive. We used whole transcriptome sequencing of 10 plasma samples with tumor‐informed… read more here.
Keywords: minimally invasive; ductal adenocarcinoma; adenocarcinoma pdac; pdac subtype ... See more keywords
Abstract 2979: 3D systems to study pancreatic ductal adenocarcinoma (PDAC). Comparison of the most referenced models using a bibliometric approach
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-2979
Abstract: Introduction: The use of 3D models to study pancreatic ductal adenocarcinoma (PDAC) has evolved in the last years. There are several described models all of which may seem to be equally relevant. However, which of… read more here.
Keywords: methodology; adenocarcinoma pdac; cancer; study pancreatic ... See more keywords
Abstract 6515: Pancreatic ductal adenocarcinoma (PDAC) early detection
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6515
Abstract: Introduction Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is one of the deadliest cancer in the U.S., with a 5-year survival rate of just 11%. It is expected that… read more here.
Keywords: adenocarcinoma pdac; ductal adenocarcinoma; detection; pancreatic ductal ... See more keywords
Abstract 494: Identifying vulnerabilities in basal-like pancreatic adenocarcinoma (PDAC)
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DOI: 10.1158/1538-7445.am2025-494
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease, with a 5-year survival of only 12.5%. There are two transcriptomic PDAC tumor subtypes: classical and basal-like. Basal-like PDAC is associated with worse patient outcomes and… read more here.
Keywords: basal like; adenocarcinoma pdac; pdac; like pdac ... See more keywords
Abstract A41: Cancer-associated fibroblast (CAF) specific biomarkers in pancreatic ductal adenocarcinoma (PDAC): Transcriptomic and molecular insight
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DOI: 10.1158/1538-7445.panca19-a41
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of malignancy-related death with poor prognosis. The late diagnosis due to nonspecific symptoms, highly aggressive nature, intrinsic resistance to chemotherapeutic, and the lack of effective therapeutic are the main… read more here.
Keywords: pdac; adenocarcinoma pdac; cancer; pancreatic ductal ... See more keywords
Abstract IA-01: Role of the gut-tumor microbial axis in pancreatic ductal adenocarcinoma (PDAC)
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DOI: 10.1158/1538-7445.panca20-ia-01
Abstract: Even though Pancreatic Ductal Adenocarcinoma (PDAC) has a 5-year survival rate of 9%, there is a minority of patients that survive more than 5 years (Long Term Survivors, LTS). Genomic studies have not shown a… read more here.
Keywords: adenocarcinoma pdac; pancreatic ductal; ductal adenocarcinoma; role gut ... See more keywords
Clinical activity of EBC-129, a first-in class, anti N256-glycosylated CEACAM5 and CEACAM6 antibody-drug conjugate (ADC), in patients with pancreatic ductal adenocarcinoma (PDAC) in a phase 1 study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.4018
Abstract: 4018 Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited treatment options. EBC-129 is a first in class MMAE-linked ADC against N256-glycosylated CEACAM5/6 antigen. Pre-screening data shows 73% of PDAC express surface antigen… read more here.
Keywords: treatment; ductal adenocarcinoma; adenocarcinoma pdac; ebc 129 ... See more keywords
The Effects of Treatment on Peripheral Blood Immune Cell Profile in Pancreatic Ductal Adenocarcinoma (PDAC)
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DOI: 10.21873/anticanres.15794
Abstract: Background/Aim: This study evaluated whether circulating lymphocytes, assessed by flow cytometry, is a prognostic biomarker in pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: We studied T cell subsets in blood samples from a cohort of… read more here.
Keywords: adenocarcinoma pdac; ductal adenocarcinoma; peripheral blood; pancreatic ductal ... See more keywords
Gene Expression Characteristics of Tumor and Adjacent Non-Tumor Tissues of Pancreatic Ductal Adenocarcinoma (PDAC) In-Silico
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2021.292558.3092
Abstract: Background: One of the deadliest and most prevalent cancer is pancreatic ductal adenocarcinoma (PDAC). Microarray has become an important tool in the research of PDAC genes and target therapeutic drugs. Objectives: This study intends to… read more here.
Keywords: adenocarcinoma pdac; ductal adenocarcinoma; expression; gene expression ... See more keywords
Pancreatic Ductal Adenocarcinoma (PDAC): A Review of Recent Advancements Enabled by Artificial Intelligence
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DOI: 10.3390/cancers16122240
Abstract: Simple Summary Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the deadliest forms of cancer, characterized by high rates of metastasis, late detection, and poor prognoses. Artificial intelligence and machine learning (AI/ML) have proven to be… read more here.
Keywords: ductal adenocarcinoma; adenocarcinoma pdac; artificial intelligence; review ... See more keywords
Inflammatory Processes: Key Mediators of Oncogenesis and Progression in Pancreatic Ductal Adenocarcinoma (PDAC)
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DOI: 10.3390/ijms252010991
Abstract: Associations between inflammation and cancer were first discovered approximately 160 years ago by Rudolf Virchow, who observed that tumors were infiltrated with inflammatory cells, and defined inflammation as a pathological condition. Inflammation has now emerged… read more here.
Keywords: key mediators; ductal adenocarcinoma; adenocarcinoma pdac; inflammatory processes ... See more keywords