Colorectal carcinoma occurring via the adenoma–carcinoma pathway in patients with serrated polyposis syndrome
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DOI: 10.1007/s00535-022-01858-8
Abstract: Although serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, the carcinogenic mechanisms remain unknown. We investigated clinicopathological characteristics and genetic abnormalities in colorectal polyps and CRC to elucidate carcinogenic mechanisms… read more here.
Keywords: serrated polyposis; carcinoma pathway; carcinoma; adenoma carcinoma ... See more keywords
PO-334 Distribution of copy number alterations defines clonal populations involved in the evolutionary transition from adenoma-to-carcinoma in colorectal cancer
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DOI: 10.1136/esmoopen-2018-eacr25.364
Abstract: Introduction Colorectal cancer progresses in a multi-step manner with adenoma being the most well-known precursor lesion. Malignant polyps, which are adenomas containing a focus of adenocarcinoma, are suitable models to study the evolution of colorectal… read more here.
Keywords: adenoma; carcinoma; copy number; transition ... See more keywords
Correlations between Intestinal Microbiota and Clinical Characteristics in Colorectal Adenoma/Carcinoma
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DOI: 10.1155/2022/3140070
Abstract: Background Most of colorectal cancer (CRC) cases are sporadic and develop along the adenoma-carcinoma sequence. Intestinal microbial dysbiosis is involved in the development of colorectal cancer. However, there are still no absolute markers predicting the… read more here.
Keywords: intestinal microbiota; colorectal adenoma; adenoma carcinoma; clinical characteristics ... See more keywords
Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence
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DOI: 10.1159/000510919
Abstract: Duodenal tumors with a sporadic adenoma-carcinoma sequence are extremely rare. For such clinically suspected cases without a specific family history, performing a comprehensive gene search is important to understand the germline mutation background. We present… read more here.
Keywords: adenoma; carcinoma; carcinoma sequence; duodenal carcinoma ... See more keywords
Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition
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DOI: 10.1186/s12885-019-6180-5
Abstract: BackgroundLong non-coding RNAs (lncRNAs) play a fundamental role in colorectal cancer (CRC) development, however, lncRNA expression profiles in CRC and its precancerous stages remain to be explored. We aimed to study whole genomic lncRNA expression… read more here.
Keywords: carcinoma transition; expression; adenoma carcinoma; crc ... See more keywords
Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
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DOI: 10.1371/journal.pone.0241597
Abstract: Cytologic diagnosis of thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma (FACHAC) is challenging due to cytomorphologic features that overlap with other follicular-patterned lesions. This study was designed to analyze diagnostic categories… read more here.
Keywords: fnac; follicular adenoma; thyroid follicular; adenoma carcinoma ... See more keywords
Transcriptomic Analyses of the Adenoma-Carcinoma Sequence Identify Hallmarks Associated With the Onset of Colorectal Cancer
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DOI: 10.3389/fonc.2021.704531
Abstract: The concept of the adenoma-carcinoma sequence in colorectal cancer (CRC) is widely accepted. However, the relationship between the characteristics of the transcriptome and the adenoma-carcinoma sequence in CRC remains unclear. Here, the transcriptome profiles of… read more here.
Keywords: colorectal cancer; carcinoma sequence; adenoma carcinoma; crc ... See more keywords
Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression
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DOI: 10.3390/cancers14092248
Abstract: Simple Summary The role of mast cells in the tumor microenvironment (TME) remains controversial but has become increasingly evident and explored as a possible therapeutic target. In this study, we investigated the underexplored mast cell… read more here.
Keywords: mucosal mast; role; mast; adenoma carcinoma ... See more keywords
miRNome Profiling and Functional Analysis Reveal Involvement of hsa-miR-1246 in Colon Adenoma-Carcinoma Transition by Targeting AXIN2 and CFTR
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DOI: 10.3390/ijms23042107
Abstract: Regulatory changes occurring early in colorectal cancer development remain poorly investigated. Since the majority of cases develop from polyps in the adenoma-carcinoma transition, a search of early molecular features, such as aberrations in miRNA expression… read more here.
Keywords: hsa; adenoma carcinoma; hsa mir; carcinoma transition ... See more keywords
Alteration of the abundance of Parvimonas micra in the gut along the adenoma-carcinoma sequence
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DOI: 10.3892/ol.2020.11967
Abstract: Parvimonas micra (P. micra) is reported to be associated with colorectal cancer (CRC). However, its association with colorectal adenoma (CRA) and its role in the initiation of colorectal tumors remain unknown. The present study aimed… read more here.
Keywords: carcinoma sequence; micra; abundance; adenoma carcinoma ... See more keywords