Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K–AKT pathway
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DOI: 10.1002/gcc.22396
Abstract: Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer‐related genes… read more here.
Keywords: tubular lactating; adenomas; lactating ductal; med12 ... See more keywords
Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam
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DOI: 10.1002/ijc.33757
Abstract: Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is an important precursor of colorectal cancer. There is currently no study to determine the modifiable risk factors for colorectal adenomas, including… read more here.
Keywords: adenomas; prevalence; association; cancer ... See more keywords
Single Gland, Ectopic Location: Adenomas are Common Causes of Primary Hyperparathyroidism in Children and Adolescents
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DOI: 10.1007/s00268-019-05362-8
Abstract: Background Primary hyperparathyroidism (PHPT) in children and adolescents is uncommon. Data-driven guidelines for management in pediatric patients are limited. Methods We performed a retrospective cohort analysis of all patients (1997–2017) with PHPT ≤ 21 years of age who… read more here.
Keywords: primary hyperparathyroidism; adenomas; phpt; children adolescents ... See more keywords
Ki-67 labeling index and expression of p53 are non-predictive for invasiveness and tumor size in functional and nonfunctional pituitary adenomas
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DOI: 10.1007/s00701-019-03879-4
Abstract: BackgroundIt is still controversial whether an increased proliferation index is correlated with the tumor invasiveness of pituitary adenomas. A homogeneous large monocentric series of pituitary adenomas was retrospectively analyzed. The correlation between the proliferation indices… read more here.
Keywords: pituitary adenomas; adenomas; expression; p53 ... See more keywords
Comprehensive analysis of the immunological landscape of pituitary adenomas: implications of immunotherapy for pituitary adenomas
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DOI: 10.1007/s11060-020-03636-z
Abstract: Immunotherapies for solid tumor are gaining traction in the clinic, however, the immunological landscape of pituitary adenomas (PAs) is not well defined. In the present study, we used the RNA-seq data of PAs to investigate… read more here.
Keywords: pas; adenomas; pituitary adenomas; immunological landscape ... See more keywords
Definition and diagnosis of aggressive pituitary tumors
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DOI: 10.1007/s11154-019-09531-x
Abstract: Pituitary adenomas are considered benign tumors, but approximately 10% of them can have an aggressive behavior and more rarely (0.2%) can present metastasis, being classified as pituitary carcinomas. Aggressive adenomas are generally large and invasive… read more here.
Keywords: diagnosis; aggressive pituitary; adenomas; diagnosis aggressive ... See more keywords
Lineage-dependent role of miR-410-3p as oncomiR in gonadotroph and corticotroph pituitary adenomas or tumor suppressor miR in somatotroph adenomas via MAPK, PTEN/AKT, and STAT3 signaling pathways
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DOI: 10.1007/s12020-019-01960-7
Abstract: PurposemiR-410-3p plays opposite roles in different cancers and may act as an oncomiR or tumor suppressor miR. The purpose of this study was to assess the role of miR-410-3p in somatotroph, gonadotroph, and corticotroph pituitary… read more here.
Keywords: gonadotroph corticotroph; tumor suppressor; mir; adenomas ... See more keywords
Cyclin A in nonfunctioning pituitary adenomas
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DOI: 10.1007/s12020-020-02402-5
Abstract: Purpose Assess cyclin A in nonfunctioning pituitary adenomas (NFPA) and compare its expression in non-invasive and non-proliferative tumors with invasive and proliferative tumors (12× higher risk of recurrence). Methods Quantitative real time polymerase chain reaction… read more here.
Keywords: pituitary adenomas; adenomas; cyclin; non invasive ... See more keywords
A 2019 update on TSH-secreting pituitary adenomas
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DOI: 10.1007/s40618-019-01066-x
Abstract: Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of hyperthyroidism and they are characterized by elevated serum levels of free thyroid hormones with measurable TSH levels. TSH-omas are very infrequent, accounting for less than… read more here.
Keywords: secreting pituitary; adenomas; 2019 update; pituitary adenomas ... See more keywords
Next-generation sequencing identifies novel mitochondrial variants in pituitary adenomas
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DOI: 10.1007/s40618-019-1005-6
Abstract: PurposeDisrupted mitochondrial functions and genetic variants of mitochondrial DNA (mtDNA) have been observed in different human neoplasms. Next-generation sequencing (NGS) can be used to detect even low heteroplasmy-level mtDNA variants. We aimed to investigate the… read more here.
Keywords: adenomas; pituitary adenomas; sequencing identifies; next generation ... See more keywords
Case series of non-ampullary duodenal adenomas
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DOI: 10.1016/j.amsu.2021.102730
Abstract: Duodenal adenomas are benign tumours of the duodenum which carry a malignant potential. They are found either sporadically or associated with familial syndromes. Majority of these cases are treated endoscopically but surgical resection is a… read more here.
Keywords: duodenal adenomas; ampullary duodenal; series non; non ampullary ... See more keywords