Novel β‐catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29584
Abstract: b -Catenin, a 781–amino acid, 85.5-kDa scaffold protein, serves a range of molecular functions including cell-to-cell adhesion to gene transcription. It is highly evolutionarily conserved and indispensable for embryonic development. bCatenin is a binding partner… read more here.
Keywords: catenin; catenin farnesoid; acid; adenomatous polyposis ... See more keywords
Resorting the function of the colorectal cancer gatekeeper adenomatous polyposis coli
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32557
Abstract: As a large number of cancers are caused by nonsense mutations in key genes, read‐through of these mutations to restore full‐length protein expression is a potential therapeutic strategy. Mutations in the adenomatous polyposis coli (APC)… read more here.
Keywords: polyposis coli; number; nonsense mutations; polyposis ... See more keywords
Immunolocalization of adenomatous polyposis coli protein (apc) in the regenerating lizard tail suggests involvement in tissue differentiation and regulation of growth
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Morphology"
DOI: 10.1002/jmor.21465
Abstract: Lizard tail regeneration is likely regulated by the balanced activity of oncogenes and tumor suppressors that control cell proliferation avoiding tumorigenic degeneration. One of the main tumor suppressor genes present in the regenerating tail is… read more here.
Keywords: adenomatous polyposis; lizard tail; protein apc; differentiation ... See more keywords
Genetic alteration of colorectal adenoma‐carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1348
Abstract: Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and adenocarcinoma that is frequently accompanied by extracolonic neoplasm. The risk of gastric carcinoma is increasing in Western FAP patients as well as Asian patients. read more here.
Keywords: carcinoma; familial adenomatous; genetic alteration; adenocarcinoma ... See more keywords
A novel large germ line deletion in adenomatous polyposis coli (APC) gene associated with familial adenomatous polyposis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.479
Abstract: Familial adenomatous polyposis (FAP) is a familial colorectal cancer predisposition syndrome characterized by the development of numerous colorectal polyps, which is inherited in an autosomal dominant manner. FAP is caused by germ line mutations in… read more here.
Keywords: germ line; apc gene; familial adenomatous; polyposis ... See more keywords
Dento-osseous anomalies in patients with familial adenomatous polyposis: A follow-up study
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-020-03220-9
Abstract: Objective The aim of this longitudinal study was to characterize the dento-osseous phenotype of eleven familial adenomatous polyposis (FAP) patients and twenty-two family members from four Brazilian families who were followed over nine years and… read more here.
Keywords: osseous anomalies; study; dento osseous; fap patients ... See more keywords
Burkitt-like lymphoma in a pediatric patient with familial adenomatous polyposis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.09.001
Abstract: Familial adenomatous polyposis (FAP) is an autosomal dominant condition that predisposes to multiple malignancies, most commonly colorectal carcinoma, but has rarely been associated with lymphoma. We discuss one patient found to have Burkitt-like Lymphoma (BLL)… read more here.
Keywords: burkitt like; adenomatous polyposis; familial adenomatous; like lymphoma ... See more keywords
Necessity of multiplex ligation probe amplification in genetic tests: Germline variant analysis of the APC gene in familial adenomatous polyposis patients.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2022.02.002
Abstract: BACKGROUND Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary cancer syndrome characterized by hundreds to thousands of colorectal adenomatous polyps. Without treatment, progression to colorectal cancer is inevitable. Most pathogenic mutations in the APC… read more here.
Keywords: adenomatous polyposis; probe amplification; familial adenomatous; multiplex ligation ... See more keywords
Upper GI involvement in children with familial adenomatous polyposis syndrome: single-center experience and meta-analysis of the literature.
Sign Up to like & getrecommendations! Published in 2018 at "Gastrointestinal endoscopy"
DOI: 10.1016/j.gie.2017.10.043
Abstract: BACKGROUND AND AIMS Familial adenomatous polyposis (FAP) is a hereditary syndrome that can affect the entire GI tract. Current screening recommendations include EGD starting at age 25 to 30 years or earlier in symptomatic patients.… read more here.
Keywords: children fap; involvement children; familial adenomatous; upper involvement ... See more keywords
Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00532
Abstract: Despite advances in targeted anticancer therapies, there are still no small-molecule-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of… read more here.
Keywords: colorectal cancer; chemistry; polyposis coli; coli apc ... See more keywords
Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0267-3
Abstract: The adenomatous polyposis coli (APC) protein has a tumor-suppressor function by acting as a negative regulator of the Wnt signaling pathway. While its role as a tumor suppressor is well-defined, the post-translational modifications that regulate… read more here.
Keywords: catenin; polyposis coli; mkrn1; adenomatous polyposis ... See more keywords