In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201906022
Abstract: Approaches that enable innate repair mechanisms hold great potential for tissue repair. Herein, biomaterial-assisted sequestration of small molecules is described to localize pro-regenerative signaling at the injury site. Specifically, a synthetic biomaterial containing boronate molecules… read more here.
Keywords: sequestration; small molecules; sequestration innate; adenosine ... See more keywords
Targeting the Negative Feedback of Adenosine-A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104182
Abstract: The metabolite adenosine plays an important immunosuppressive role in the tumor microenvironment (TME) through its ligation with the metabolic checkpoint adenosine 2A receptor (A2AR). Here, an adenosine-A2AR negative feedback pathway is highlighted during photothermal-induced immunogenic… read more here.
Keywords: tumor; adenosine a2ar; a2ar metabolic; negative feedback ... See more keywords
Identification of 2‐Methylthio‐methylenethio‐N6‐(cis‐4‐hydroxyisopentenyl)adenosine (msms2io6A37) as a Novel Modification at Adenosine 37 of tRNAs from Salmonella typhimurium
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300019
Abstract: Post‐transcriptional modifications of tRNA nucleotide are important determinants in folding, structure and function. We have successfully identified and characterized a new modified base named 2‐methylthio‐methylenethio‐N6‐(cis‐4‐hydroxyisopentenyl)adenosine, which is present at position 37 in some tRNAs. We… read more here.
Keywords: salmonella typhimurium; adenosine; hydroxyisopentenyl adenosine; cis hydroxyisopentenyl ... See more keywords
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700151
Abstract: Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A1 receptors (A1Rs) has been shown to… read more here.
Keywords: a1r; agonist; treatment heart; bialanate hydrochloride ... See more keywords
Comparison of the Human A2A Adenosine Receptor Recognition by Adenosine and Inosine: New Insight from Supervised Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700200
Abstract: Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine. Nevertheless, recent studies have demonstrated that inosine has neuroprotective, cardioprotective, immunomodulatory, and antidepressive… read more here.
Keywords: adenosine inosine; a2a adenosine; adenosine receptor; receptor recognition ... See more keywords
The adenosine monophosphate–activated protein kinase—vacuolar adenosine triphosphatase–pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30029
Abstract: Liver fibrosis and cirrhosis are characterized by activation of hepatic stellate cells (HSCs), which is associated with higher intracellular pH (pHi). The vacuolar H+ adenosine‐triphosphatase (v‐ATPase) multisubunit complex is a key regulator of pHi homeostasis.… read more here.
Keywords: atpase; ampk; activation; adenosine ... See more keywords
Extracellular adenosine‐induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier‐protective role
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26281
Abstract: We have previously shown that Gs‐coupled adenosine receptors (A2a) are primarily involved in adenosine‐induced human pulmonary artery endothelial cell (HPAEC) barrier enhancement. However, the downstream events that mediate the strengthening of the endothelial cell (EC)… read more here.
Keywords: rac1 activation; induced rac1; adenosine; adenosine induced ... See more keywords
Editorial for: “Splenic Switch‐Off for Determining the Optimal Dosage for Adenosine Stress Cardiovascular MR in Terms of Stress Effectiveness and Patient Safety”
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27252
Abstract: Imaging Modalities: Coronary artery disease (CAD) is currently a worldwide epidemic, with an ever-increasing impact on the healthcare systems. Noninvasive myocardial perfusion assessment is clinically valuable for patients with known or suspected CAD, myocardial dysfunction,… read more here.
Keywords: adenosine stress; cad; stress; adenosine ... See more keywords
The response to adenosine tells all: What is the mechanism?
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Arrhythmia"
DOI: 10.1002/joa3.13154
Abstract: The surface electrocardiograms during a wide QRS complex tachycardia and during the injection of 10 mg of adenosine triphosphate. What is the mechanism of this wide QRS tachycardia? read more here.
Keywords: adenosine tells; adenosine; response adenosine; mechanism ... See more keywords
Adenosine triphosphate energy‐independently controls protein homeostasis with unique structure and diverse mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4079
Abstract: Proteins function in the crowded cellular environments with high salt concentrations, thus facing tremendous challenges of misfolding/aggregation which represents a pathological hallmark of aging and an increasing spectrum of human diseases. Recently, intrinsically disordered regions… read more here.
Keywords: aggregation; energy; protein homeostasis; diverse mechanisms ... See more keywords
Rationally Engineered Adenosine A2A Decoy Receptor for Reversing Immunosuppression of Breast Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202504487
Abstract: The hypoxia-adenosine axis drives tumor immune evasion by activating A2AR on immune cells, and current therapeutic strategies predominantly rely on small-molecule antagonists. However, these agents face limitations including short plasma half-life, off-target effects on other… read more here.
Keywords: breast cancer; solid tumors; rationally engineered; adenosine ... See more keywords