Sinomenine increases adenosine A2A receptor and inhibits NF‐κB to inhibit arthritis in adjuvant‐induced‐arthritis rats and fibroblast‐like synoviocytes through α7nAChR
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0121-024rrrr
Abstract: Sinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti‐inflammatory… read more here.
Keywords: a2a receptor; adenosine a2a; sin; arthritis ... See more keywords
Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson’s disease mice model
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03670-0
Abstract: Parkinson’s disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to… read more here.
Keywords: curcumin niacin; adenosine a2a; a2a receptor; parkinson disease ... See more keywords
Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02275-9
Abstract: Angelman syndrome (AS) is a neurogenetic disorder involving ataxia and motor dysfunction, resulting from the absence of the maternally inherited functional Ube3a protein in neurons. Since adenosine A2A receptor (A2AR) blockade relieves synaptic and motor… read more here.
Keywords: adenosine a2a; a2a receptor; blockade; angelman syndrome ... See more keywords
Adenosine A2A receptor involves in neuroinflammation-mediated cognitive decline through activating microglia under acute hypobaric hypoxia
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.02.038
Abstract: HighlightsAcute HH induced cognitive impairments and neuroinflammation in the hippocampus.Genetic A2AR deletion attenuated acute HH‐induced impairment of spatial memory.Hippocampal A2ARs were mainly expressed on microglia and up‐regulated in acute HH model of mice.Microglia‐mediated neuroinflammation by… read more here.
Keywords: a2ar; spatial memory; adenosine a2a; hypobaric hypoxia ... See more keywords
Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORγt) signaling in a BTBR T+ Itpr3tf/J mouse model of autism.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.04.014
Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by abnormal social interactions, repetitive behaviors that impair social communication, and circumscribed interests. BTBR T+tf/J (BTBR) inbred mice are generally used as a model for… read more here.
Keywords: adenosine a2a; ror; 17a ror; expression levels ... See more keywords
Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.05.033
Abstract: &NA; G protein‐coupled adenosine receptors are promising therapeutic targets for a wide range of neuropathological conditions, including Parkinson's disease (PD). However, the ubiquity of adenosine receptors and the ultimate lack of selectivity of certain adenosine‐based… read more here.
Keywords: receptor; adenosine a2a; mrs7145; movement disorders ... See more keywords
Adenosine A2A receptor blockade attenuates spatial memory deficit and extent of demyelination areas in lyolecithin‐induced demyelination model
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.05.007
Abstract: &NA; In recent years, inactivation of A2A adenosine receptors has been emerged as a novel strategy for treatment of several neurodegenerative diseases. Although numerous studies have shown the beneficial effects of A2A receptors blockade on… read more here.
Keywords: demyelination; spatial memory; adenosine a2a; a2a receptor ... See more keywords
Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.10.022
Abstract: &NA; Insomnia is one of the most common sleep problems with an estimated prevalence of 10%–15% in the general population. Although adenosine A2A receptor (A2AR) agonists strongly induce sleep, their cardiovascular effects preclude their use… read more here.
Keywords: adenosine a2a; a2a receptor; wave sleep; a2ar pam ... See more keywords
Adenosine A2A Receptor Antagonists for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00237
Abstract: Currently, the most promising therapeutic modality for cancer treatment is the blockade of immune checkpoint pathways, which has revolutionized cancer therapy in the last 15 years. Strategies targeting and modulating adenosine A2A receptor (A2AR), an… read more here.
Keywords: cancer; adenosine a2a; a2a receptor;
Heterobivalent Ligand for the Adenosine A2A-Dopamine D2 Receptor Heteromer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01763
Abstract: A G protein-coupled receptor heteromer that fulfills the established criteria for its existence in vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors. Here, we have designed and synthesized heterobivalent ligands… read more here.
Keywords: heteromer; receptor heteromer; adenosine a2a;
Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02199
Abstract: In recent years, the adenosine A2A receptor (A2AR) has shown exciting progress in the development of immunotherapies for the treatment of cancer. Herein, a 2-amino-7,9-dihydro-8H-purin-8-one compound (1) was identified as an A2AR antagonist hit through… read more here.
Keywords: antagonists cancer; adenosine a2a; one derivatives; aminopteridin one ... See more keywords