Identification of Adenosine Deaminase Inhibitors by Metal‐binding Pharmacophore Screening
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DOI: 10.1002/cmdc.202000271
Abstract: Adenosine deaminase (ADA) is a human mononuclear Zn2+ metalloenzyme that converts adenosine to inosine. ADA is a validated drug target for cancer, but there has been little recent work on the development of new therapeutics… read more here.
Keywords: deaminase inhibitors; inhibitors metal; metal binding; identification adenosine ... See more keywords
Repeatability of pleural adenosine deaminase measurements in diagnostic evaluation of pleural effusions
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DOI: 10.1002/jcla.22371
Abstract: A follow‐up thoracentesis is proposed in suspected atypical tuberculosis cases. The study aimed to define the variability of pleural ADA values across repeated thoracenteses in different types of pleural effusions (PEs) and to evaluate whether… read more here.
Keywords: deaminase measurements; repeatability pleural; pleural adenosine; adenosine deaminase ... See more keywords
How We Manage Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA SCID)
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DOI: 10.1007/s10875-017-0373-y
Abstract: Adenosine deaminase-deficient severe combined immune deficiency (ADA SCID) accounts for 10–15% of cases of human SCID. From what was once a uniformly fatal disease, the prognosis for infants with ADA SCID has improved greatly based… read more here.
Keywords: adenosine deaminase; ada scid; deficient severe; deaminase deficient ... See more keywords
Long-Term Outcome of Adenosine Deaminase-Deficient Patients—a Single-Center Experience
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DOI: 10.1007/s10875-017-0421-7
Abstract: PurposeInherited defects in the adenosine deaminase (ADA) enzyme can cause severe combined immune deficiency (SCID) and systemic abnormalities. Management options for ADA-deficient patients include enzyme replacement therapy (ERT), hematopoietic stem cell transplantation (HSCT), and gene… read more here.
Keywords: deficient patients; single center; term; long term ... See more keywords
Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations
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DOI: 10.1007/s10875-017-0433-3
Abstract: Deficiency of adenosine deaminase (ADA, EC3.5.4.4), a housekeeping enzyme of purine metabolism encoded by the Ada gene, is a cause of human severe combined immune deficiency (SCID). Numerous deleterious mutations occurring in the ADA gene… read more here.
Keywords: combined immune; immune deficiency; adenosine deaminase; deficiency ... See more keywords
Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
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DOI: 10.1007/s10875-021-01098-0
Abstract: Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and… read more here.
Keywords: hematopoietic cell; adenosine deaminase; deficiency; cell transplantation ... See more keywords
Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine.
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DOI: 10.1016/j.abb.2019.04.002
Abstract: Plasmodium falciparum (Pf), a malarial pathogen, can only synthesize purine nucleotides employing a salvage pathway because it lacks de novo biosynthesis. Adenosine deaminase (ADA), one of the three purine salvage enzymes, catalyzes the irreversible hydrolytic… read more here.
Keywords: binding pocket; plasmodium falciparum; structure; plasmodium ... See more keywords
Biologic drugs in the treatment of polyarteritis nodosa and deficit of adenosine deaminase 2: A narrative review.
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DOI: 10.1016/j.autrev.2021.102784
Abstract: Polyarteritis nodosa (PAN) is a medium vessels vasculitis variously involving different organs and systems, sometimes with an aggressive course, leading to death or disability in a significant number of cases. First-line treatment usually relies on… read more here.
Keywords: polyarteritis nodosa; deficit adenosine; biologic drugs; treatment ... See more keywords
Citrullination of adenosine deaminase impairs its binding to dipeptidyl peptidase IV.
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DOI: 10.1016/j.bpc.2022.106820
Abstract: The presence of citrullinated adenosine deaminase (ADA) was reported in the synovial fluids of rheumatoid arthritis individuals. This work reports the effects of ADA citrullination on the formation/stabilization of ADA complex with dipeptidyl peptidase IV… read more here.
Keywords: dipeptidyl peptidase; ada; citrullination; adenosine deaminase ... See more keywords
Adenosine deaminase inhibition.
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DOI: 10.1016/j.ijbiomac.2019.09.078
Abstract: Adenosine deaminase is a critical enzyme in purine metabolism that regulates intra and extracellular adenosine concentrations by converting it to inosine. Adenosine is an important purine that regulates numerous physiological functions by interacting with its… read more here.
Keywords: adenosine deaminase; deaminase; deaminase inhibition;
Aflatoxins produced by Aspergillus parasiticus present in the diet of quails increase the activities of cholinesterase and adenosine deaminase.
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DOI: 10.1016/j.micpath.2017.03.041
Abstract: The aim of this study was to evaluate the effects of aflatoxins on cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and adenosine deaminase (ADA) activities in quails. For this, twenty male quails were randomly distributed into… read more here.
Keywords: ache; ada; group; adenosine deaminase ... See more keywords