New Efficient Synthesis of tRNA Related Adenosines Bearing the Hydantoin Ring (ct6A, ms2ct6A) by Intramolecular Cyclization of N6‐(N‐Boc‐α‐aminoacyl)‐adenosine Derivatives
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DOI: 10.1002/cbic.202100655
Abstract: A novel and efficient way for the synthesis of N6‐hydantoin‐modified adenosines, which utilizes readily available N6‐(N‐Boc‐α‐aminoacyl)‐adenosine derivatives, was developed. The procedure is based on the epimerization‐free, Tf2O‐mediated conversion of the Boc group into an isocyanate… read more here.
Keywords: aminoacyl adenosine; adenosine derivatives; boc; hydantoin ... See more keywords
Tetraphenylethene-based tetracationic cyclophanes and their selective recognition for amino acids and adenosine derivatives in water.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc00599d
Abstract: Two new tetracationic cyclophanes 1 and 2 containing tetraphenylethene and bipyridinium moieties were synthesized via a two-step SN2 reaction. These water-soluble cyclophanes with a cationic and hydrophobic cavity exhibited selective recognition for amino acids (e.g.… read more here.
Keywords: amino acids; selective recognition; water; recognition amino ... See more keywords
Two New Adenosine Derivatives and their Antiproliferative Properties, an In Vitro Evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210528151818
Abstract: BACKGROUND Adenosine is a natural nucleoside present in various organs and tissues, where it acts as a modulator of diverse physiological and pathophysiological processes. These actions are mediated by at least four G protein-coupled receptors,… read more here.
Keywords: cell lines; two new; antiproliferative properties; cancer ... See more keywords
Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents.
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DOI: 10.3390/molecules23051111
Abstract: We describe the semisynthesis and biological effects of adenosine derivatives, which were anticipated to function as agonists for the A3 receptor. Molecular docking was used to select candidate compounds. Fifteen nucleoside derivatives were obtained through… read more here.
Keywords: derivatives antiproliferative; characterization evaluation; semisynthesis characterization; evaluation new ... See more keywords
Understanding Parahydrogen Hyperpolarized Urine Spectra: The Case of Adenosine Derivatives
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DOI: 10.3390/molecules27030802
Abstract: Parahydrogen hyperpolarization has emerged as a promising tool for sensitivity-enhanced NMR metabolomics. It allows resolution and quantification of NMR signals of certain classes of low-abundance metabolites that would otherwise be undetectable. Applications have been implemented… read more here.
Keywords: adenosine derivatives; parahydrogen hyperpolarized; parahydrogen; hyperpolarized urine ... See more keywords