Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models
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DOI: 10.1002/cncr.32600
Abstract: Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance. This study explores the role of autophagy in regulating the sensitivity of ovarian… read more here.
Keywords: drug resistance; adenosine diphosphate; poly adenosine; ribose polymerase ... See more keywords
Adenosine diphosphate ribose cyclase: An important regulator of human pathological and physiological processes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30688
Abstract: Adenosine diphosphate ribose cyclase (ADPRC) exists widely in eukaryotes and lower metazoans cells. It can degrade nicotinamide adenine dinucleotide (NAD) into cyclic ADP ribose (cADPR) and nicotinamide, and subsequently hydrolyses cADPR to ADP ribose (ADPR).… read more here.
Keywords: adenosine diphosphate; cyclase important; diphosphate ribose; ribose cyclase ... See more keywords
The metabolism of ecto-5’-nucleotidase (CD73) inhibitor-α,β-methylene adenosine diphosphate in BALB/c mice
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DOI: 10.1080/15257770.2018.1489052
Abstract: Abstract CD73 inhibitors are considered to be used in the therapies of melanomas, gliomas or breast cancer. However, little is known about their pharmacology and kinetics in mouse experimental models. Thus, this study is aimed… read more here.
Keywords: adenosine diphosphate; blood; mice; balb mice ... See more keywords
Adenosine diphosphate‐induced aggregation is enhanced in platelets obtained from patients with thrombotic primary antiphospholipid syndrome (t‐PAPS): Role of P2Y12‐cAMP signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15724
Abstract: Thrombotic antiphospholipid syndrome (t‐PAPS) is characterized by arterial, venous, or microvascular occlusions, which are explained, in part, by the presence of antiphospholipid (aPL) antibodies. Although there is much evidence indicating that isolated aPL antibodies increase… read more here.
Keywords: adenosine diphosphate; platelets obtained; diphosphate induced; syndrome paps ... See more keywords
Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors
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DOI: 10.18632/oncotarget.16859
Abstract: Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. Although they have been considered as resident nuclear elements of the… read more here.
Keywords: adenosine diphosphate; poly adp; target; poly adenosine ... See more keywords
Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation
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DOI: 10.3389/fimmu.2021.651740
Abstract: Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden to patients, it challenges wound care professionals and causes a great financial cost to health system. Considering… read more here.
Keywords: wound healing; adenosine diphosphate; receptor; adp ... See more keywords
Aqueous Extract of Tournefortia sarmentosa Stem Inhibits ADP-induced Platelet Aggregation
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DOI: 10.4172/pharmaceutical-sciences.1000337
Abstract: Tournefortia sarmentosa is a Chinese herbal medicine used as an antioxidant, detoxicant, and anti-inflammatory agent. The present study evaluated the effect of T. sarmentosa on adenosine diphosphate-induced platelet aggregation. Our results showed that aqueous stem… read more here.
Keywords: induced platelet; adenosine diphosphate; platelet aggregation; stem ... See more keywords