Comparison of the Human A2A Adenosine Receptor Recognition by Adenosine and Inosine: New Insight from Supervised Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700200
Abstract: Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine. Nevertheless, recent studies have demonstrated that inosine has neuroprotective, cardioprotective, immunomodulatory, and antidepressive… read more here.
Keywords: adenosine inosine; a2a adenosine; adenosine receptor; receptor recognition ... See more keywords
Single-Base Resolution Detection of Adenosine-to-Inosine RNA Editing by Endonuclease-Mediated Sequencing.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01226
Abstract: RNA molecules contain diverse modifications that play crucial roles in a wide variety of biological processes. Adenosine-to-inosine (A-to-Ino) RNA editing is one of the most prevalent modifications among all types of RNA. Abnormal A-to-InoRNA editing… read more here.
Keywords: rna editing; rna; hendov; ino ... See more keywords
Adenosine-to-Inosine RNA Editing and N6-Methyladenosine Modification Modulating Expression of Drug Metabolizing Enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000390
Abstract: Interindividual differences in the expression and activity of drug metabolizing enzymes including cytochrome P450, UDP-glucuronosyltransferase, and esterases cause variable therapeutic efficacy or adverse events of drugs. As the major mechanisms causing the variability in the… read more here.
Keywords: drug metabolizing; inosine rna; drug; adenosine inosine ... See more keywords
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.200055
Abstract: ABSTRACT Adenosine to inosine (A-to-I) RNA editing is important for a functional brain, and most known sites that are subject to selective RNA editing have been found to result in diversified protein isoforms that are… read more here.
Keywords: adenosine inosine; rna; adar2; inosine rna ... See more keywords
PRESa2i: incremental decision trees for prediction of Adenosine to Inosine RNA editing sites
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.22823.1
Abstract: RNA editing is a very crucial cellular process affecting protein encoding and is sometimes correlated with the cause of fatal diseases, such as cancer. Thus knowledge about RNA editing sites in a RNA sequence is… read more here.
Keywords: adenosine inosine; incremental decision; rna; editing sites ... See more keywords
Development and Validation of a Four Adenosine-to-Inosine RNA Editing Site-Relevant Prognostic Signature for Assessing Survival in Breast Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.861439
Abstract: Background Adenosine-to-inosine RNA editing (ATIRE) is increasingly being used to characterize cancer. However, no studies have been conducted to identify an ATIRE signature for predicting cancer survival. Methods Breast cancer (BRCA) samples with ATIRE profiles… read more here.
Keywords: cancer; validation; signature; atire ... See more keywords