Targeting the adenosine pathway for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in immunology"
DOI: 10.1016/j.smim.2019.101304
Abstract: Suppression of anti-tumor immunity is recognized as a critical step in the development of many types of cancers. Over the past decade, a multitude of immunosuppressive pathways occurring in the tumor microenvironment (TME) have been… read more here.
Keywords: adenosine pathway; cancer immunotherapy; pathway cancer; cancer ... See more keywords
Targeting CD39 in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-020-0376-4
Abstract: The ATP–adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumour microenvironment. Consequently, multiple clinical strategies are being explored to target this pathway for the treatment of cancer; in particular,… read more here.
Keywords: immunity; adenosine pathway; pathway; atp adenosine ... See more keywords
Adenosine pathway inhibitors: novel investigational agents for the treatment of metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2078191
Abstract: ABSTRACT Introduction The adenosine pathway has been suggested to play a key role in several carcinogenetic processes, with the metabolism of adenosine-5′-triphosphate (ATP) and its derivatives reported to be dysregulated in breast cancer. Preclinical evidence… read more here.
Keywords: pathway inhibitors; breast cancer; pathway; adenosine pathway ... See more keywords
Methotrexate activated Tregs via the CD73/AMPK/mTOR pathway
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.17165
Abstract: Psoriasis is a common skin disease that affects about 2% to 3% of people. The cause is unknown and believed to involve the genes and immune system, and the treatments we use now can control… read more here.
Keywords: methotrexate activated; adenosine pathway; regulatory cells; pathway ... See more keywords
Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004089
Abstract: Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and CD39 in development. Through a cyclic-AMP-mediated intracellular cascade, adenosine shifts the cytokine and… read more here.
Keywords: oncology; cell; adenosine; adenosine pathway ... See more keywords
Tumor intrinsic and extrinsic functions of CD73 and the adenosine pathway in lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1130358
Abstract: The adenosine pathway is an exciting new target in the field of cancer immunotherapy. CD73 is the main producer of extracellular adenosine. Non-small cell lung cancer (NSCLC) has one of the highest CD73 expression signatures… read more here.
Keywords: pathway lung; lung cancer; adenosine pathway; cancer ... See more keywords