Comparison of the Human A2A Adenosine Receptor Recognition by Adenosine and Inosine: New Insight from Supervised Molecular Dynamics Simulations
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DOI: 10.1002/cmdc.201700200
Abstract: Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine. Nevertheless, recent studies have demonstrated that inosine has neuroprotective, cardioprotective, immunomodulatory, and antidepressive… read more here.
Keywords: adenosine inosine; a2a adenosine; adenosine receptor; receptor recognition ... See more keywords
Targeting G Protein‐Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor
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DOI: 10.1002/cmdc.202000466
Abstract: The A3 adenosine receptor (AR) is a G protein‐coupled receptor (GPCR) overexpressed in the membrane of specific cancer cells. Thus, the development of nanosystems targeting this receptor could be a strategy to both treat and… read more here.
Keywords: adenosine receptor; carbon nanotubes; protein coupled; cancer ... See more keywords
Therapeutic potential of A2 adenosine receptor pharmacological regulators in the treatment of cardiovascular diseases, recent progress, and prospective
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DOI: 10.1002/jcp.27161
Abstract: Adenosine and its analogs are of particular interest as potential therapeutic agents for treatment of cardiovascular diseases (CVDs). A2 adenosine receptor subtypes (A2a and A2b) are extensively expressed in cardiovascular system, and modulation of these… read more here.
Keywords: adenosine receptor; pharmacological regulators; cardiovascular diseases; treatment cardiovascular ... See more keywords
Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration
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DOI: 10.1007/s00109-018-1680-3
Abstract: Osteoarthritis (OA), the most common form of arthritis, is characterized by inflammation of joints and cartilage degradation leading to disability, discomfort, severe pain, inflammation, and stiffness of the joint. It has been shown that adenosine,… read more here.
Keywords: ablation; adenosine receptor; articular cartilage; cartilage degeneration ... See more keywords
DPCPX, a selective adenosine A1 receptor antagonist, enhances the antidepressant-like effects of imipramine, escitalopram, and reboxetine in mice behavioral tests
Sign Up to like & getrecommendations! Published in 2018 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-018-1551-z
Abstract: The main goal of the present study was to evaluate the influence of the adenosine A1 receptor (A1R) antagonist — DPCPX — on depressive-like behavior in mice, as well as the effect of DPCPX on the activity of imipramine,… read more here.
Keywords: dpcpx; imipramine escitalopram; adenosine receptor; escitalopram reboxetine ... See more keywords
The adenosine A(2A) receptor agonist CGS 21680 alleviates auditory sensorimotor gating deficits and increases in accumbal CREB in rats neonatally treated with quinpirole
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DOI: 10.1007/s00213-020-05631-8
Abstract: The adenosine A(2A) receptor forms a mutually inhibitory heteromer with the dopamine D2 receptor, and A(2A) agonists decrease D2 signaling. This study analyzed whether an adenosine A(2A) agonist would alleviate deficits in sensorimotor gating and… read more here.
Keywords: agonist; sensorimotor gating; cgs 21680; adenosine receptor ... See more keywords
Adenosine and adenosine receptor-mediated action in coronary microcirculation
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DOI: 10.1007/s00395-021-00859-7
Abstract: Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in the regulation of coronary microcirculation through activation of adenosine receptors (ARs). Adenosine is regulated by various enzymes and nucleoside transporters for its… read more here.
Keywords: adenosine receptor; adenosine adenosine; coronary microcirculation; adenosine ... See more keywords
The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation
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DOI: 10.1007/s10753-018-0781-z
Abstract: Adenosine receptor activation has been explored as a modulator of the inflammatory process that propagates osteoarthritis. It has been reported that cartilage has enhanced regenerative potential when influenced by adenosine receptor activation. As adenosine’s role… read more here.
Keywords: receptor activation; adenosine; adenosine receptor; role ... See more keywords
LJ-529, a partial peroxisome proliferator-activated receptor gamma (PPARγ) agonist and adenosine A3 receptor agonist, ameliorates elastase-induced pulmonary emphysema in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of pharmacal research"
DOI: 10.1007/s12272-020-01235-0
Abstract: Chronic obstructive pulmonary disease (COPD) is the leading cause of human death worldwide. Currently available therapies for COPD mainly relieve symptoms and preserve lung function, suggesting the need to develop novel therapeutic or preventive regimens.… read more here.
Keywords: peroxisome proliferator; adenosine receptor; emphysema; elastase induced ... See more keywords
A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.11.011
Abstract: Neuropathic pain is a widespread problem which remains poorly managed by currently available therapeutics. Peripheral nerve injury and inflammation leads to changes at the nerve injury site, including activation of resident and recruited peripheral immune… read more here.
Keywords: peri sciatic; adenosine receptor; nerve injury; sciatic nerve ... See more keywords
Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor.
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DOI: 10.1016/j.bpj.2017.09.027
Abstract: By mole, cholesterol is the most abundant component of animal cell plasma membranes. Many membrane proteins have been shown to be functionally dependent on cholesterol, several of which have also been shown to bind cholesterol… read more here.
Keywords: a2a adenosine; new cholesterol; adenosine receptor; cholesterol ... See more keywords