Roles of adenosine A1 receptors in the regulation of SFK activity in the rat forebrain
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2254
Abstract: Adenosine A1 receptors are widely expressed in the mammalian brain. Through interacting with Gαi/o‐coupled A1 receptors, the neuromodulator adenosine modulates a variety of cellular and synaptic activities. To determine the linkage from A1 receptors to… read more here.
Keywords: y416 phosphorylation; activity; fyn src; adenosine receptors ... See more keywords
Adenosine A1 receptors measured with 11C‐MPDX PET in early Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Synapse"
DOI: 10.1002/syn.21979
Abstract: Adenosine A1 receptors (A1Rs) interact negatively with dopamine D1 receptors (D1Rs) in neurons of the basal ganglia's direct pathway, while adenosine A2A receptors (A2ARs) negatively interact with dopamine D2 receptors (D2Rs) in indirect‐pathway neurons. The… read more here.
Keywords: parkinson disease; adenosine receptors; mpdx pet; 11c mpdx ... See more keywords
The effects of caffeine on bone mineral density and fracture risk
Sign Up to like & getrecommendations! Published in 2022 at "Osteoporosis International"
DOI: 10.1007/s00198-021-05972-w
Abstract: Caffeine is a regular part of the diet of many adults (coffee, tea, soft drinks, and energy drinks). Multiple molecular effects of caffeine suggest that it may promote bone loss. Given the extensive consumption of… read more here.
Keywords: adenosine receptors; density; caffeine; effects caffeine ... See more keywords
Adenosine and preeclampsia.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2016.12.003
Abstract: Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, adenosine receptors, and corresponding intracellular signalling network associate… read more here.
Keywords: membrane transporters; adenosine preeclampsia; preeclampsia; adenosine receptors ... See more keywords
Mild hypothermia protects synaptic transmission from experimental ischemia through reduction in the function of nucleoside transporters in the mouse hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107853
Abstract: Ischemia, a severe metabolic stress, increases adenosine levels and causes the suppression of synaptic transmission through adenosine A1 receptors. Although temperature also regulates extracellular adenosine levels, the effect of temperature on ischemia-induced activation of adenosine… read more here.
Keywords: hypothermia; adenosine receptors; ischemia; synaptic transmission ... See more keywords
Suppression of ASIC activity by the activation of A1 adenosine receptors in rat primary sensory neurons
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108924
Abstract: Peripheral A1 adenosine receptor signaling has been shown to have analgesic effects in a variety of pain conditions. However, it is not yet fully elucidated for the precise molecular mechanisms. Acid sensing ion channels (ASICs)… read more here.
Keywords: adenosine receptors; peripheral adenosine; sensory neurons; suppression asic ... See more keywords
Kinetic Aspects of the Interaction between Ligand and G Protein-Coupled Receptor: The Case of the Adenosine Receptors.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.6b00025
Abstract: Ligand-receptor binding kinetics is an emerging topic in the drug research community. Over the past years, medicinal chemistry approaches from a kinetic perspective have been increasingly applied to G protein-coupled receptors including the adenosine receptors… read more here.
Keywords: binding kinetics; protein coupled; adenosine receptors; kinetic aspects ... See more keywords
Borneol and Α-asarone as adjuvant agents for improving blood–brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery"
DOI: 10.1080/10717544.2018.1516005
Abstract: Abstract Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain–blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting… read more here.
Keywords: adjuvant agents; pue tmp; adenosine receptors; asarone ... See more keywords
Predicting Drug Interaction With Adenosine Receptors Using Machine Learning and SMOTE Techniques
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Access"
DOI: 10.1109/access.2019.2946314
Abstract: Cancer is one of the most influential factors causing death in the world. Adenosine which is a molecule, found in all human cells by coupling with G protein it turns into an adenosine receptor. Adenosine… read more here.
Keywords: adenosine receptors; drug; machine; adenosine ... See more keywords
Potential for modulation of platelet function via adenosine receptors during inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16146
Abstract: Traditionally, platelets are well known to play an important role in haemostasis and thrombosis, however they serve also as important modulators of inflammation and immunity. Platelets secrete adhesion molecules and cytokines, interact with leukocytes and… read more here.
Keywords: platelet function; modulation platelet; adenosine receptors; potential modulation ... See more keywords
Pharmacology of Adenosine Receptors: The State of the Art.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological reviews"
DOI: 10.1152/physrev.00049.2017
Abstract: Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the… read more here.
Keywords: receptors state; pharmacology; adenosine receptors; pharmacology adenosine ... See more keywords