Adenosine Signaling in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-47189-7_9
Abstract: Adenosine, deriving from ATP released by dying cancer cells and then degradated in the tumor environment by CD39/CD73 enzyme axis, is linked to the generation of an immunosuppressed niche favoring the onset of neoplasia. Signals… read more here.
Keywords: adenosine signaling; signaling tumor; adenosine; tumor microenvironment ... See more keywords
Differential role of adenosine signaling cascade in acute and chronic pain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134483
Abstract: Adenosine is a signaling molecule induced under stress such as energy insufficiency and ischemic/hypoxic conditions. Adenosine controls multiple physiological and pathological cellular and tissue function by activation of four G protein-coupled receptors (GPCR). Functional role… read more here.
Keywords: adenosine; role adenosine; chronic pain; adenosine signaling ... See more keywords
Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-06-0377
Abstract: Extracellular adenosine signaling is established as a protective component in mucosal inflammatory responses. The sources of extracellular adenosine include enzymatic processing from nucleotides, such as ATP and AMP, that can be liberated from a variety… read more here.
Keywords: barrier; metabolism; adenosine signaling; neutrophils sources ... See more keywords
Role of adenosine signaling in preeclampsia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15066
Abstract: Placenta‐specific molecular basis that is responsible for the pathophysiology of preeclampsia (PE) remains to be fully understood. Adenosine, an endogenous nucleoside, is a signaling molecule that is induced under pathological conditions such as hypoxia and… read more here.
Keywords: role adenosine; adenosine signaling; signaling preeclampsia; adenosine ... See more keywords
Targeting adenosine for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-018-0360-8
Abstract: Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy. To extend the impact of immunotherapy… read more here.
Keywords: immunotherapy; adenosine signaling; adenosine cancer; cancer immunotherapy ... See more keywords
Adenosine signaling: Optimal target for gastric cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1027838
Abstract: Gastric cancer (GC) is one of the most common malignancy and leading cause of cancer-related deaths worldwide. Due to asymptomatic or only nonspecific early symptoms, GC patients are usually in the advanced stage at first… read more here.
Keywords: adenosine signaling; signaling optimal; optimal target; gastric cancer ... See more keywords
The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1163585
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic stroma that impedes drug delivery, reduces parenchymal blood flow, and suppresses the anti-tumor immune response. The extracellular matrix and abundance of stromal cells result in… read more here.
Keywords: adenosine signaling; adora2b receptor; adora2b; receptor ... See more keywords
The Role of Adenosine Signaling in Headache: A Review
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DOI: 10.3390/brainsci7030030
Abstract: Migraine is the third most prevalent disease on the planet, yet our understanding of its mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that… read more here.
Keywords: adenosine signaling; evidence; role; signaling headache ... See more keywords
Targeting Immunosuppressive Adenosine Signaling: A Review of Potential Immunotherapy Combination Strategies
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108871
Abstract: The tumor microenvironment regulates many aspects of cancer progression and anti-tumor immunity. Cancer cells employ a variety of immunosuppressive mechanisms to dampen immune cell function in the tumor microenvironment. While immunotherapies that target these mechanisms,… read more here.
Keywords: targeting immunosuppressive; immunosuppressive adenosine; adenosine signaling; tumor microenvironment ... See more keywords