Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.01.017
Abstract: OBJECTIVE Adenosine participates in maintaining the excitatory/inhibitory balance in neuronal circuits. Studies indicate that adenosine levels in the cortex and hippocampus increase and exert sleep pressure in sleep-deprived and control animals, whereas in epilepsy reduced… read more here.
Keywords: epilepsy; adenosine tone; adenosine; sleep disorders ... See more keywords
Targeting ENT1 and adenosine tone for the treatment of Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddw402
Abstract: &NA; Huntington's disease (HD) is caused by an abnormal CAG expansion in the exon 1 of huntingtin gene. The treatment of HD is an unmet medical need. Given the important role of adenosine in modulating… read more here.
Keywords: adenosine tone; ent1; adenosine; huntington disease ... See more keywords