Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models
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DOI: 10.1007/s11262-017-1471-x
Abstract: Helper-dependent adenoviral vectors (HDAd) are deleted of all viral genes and they can efficiently transduce a wide variety of dividing and non-dividing cells to mediate high transgene expression levels. Unlike early generation adenoviral vectors, the… read more here.
Keywords: large animal; gene therapy; adenoviral vectors; dependent adenoviral ... See more keywords
Stability of adenoviral vectors used in gene therapy
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DOI: 10.1016/j.jcyt.2020.03.391
Abstract: Background & Aim Adenoviral vectors (AdV) are still the most widely used for both in vivo administration and in vitro genetic modification of cellular therapy products. CAGT has manufactured 51 clinical grade AdV for either… read more here.
Keywords: adv; stability adenoviral; vectors used; adenoviral vectors ... See more keywords
The use of adenoviral vectors in gene therapy and vaccine approaches
Sign Up to like & getrecommendations! Published in 2022 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2022-0079
Abstract: Abstract Adenovirus was first identified in the 1950s and since then this pathogenic group of viruses has been explored and transformed into a genetic transfer vehicle. Modification or deletion of few genes are necessary to… read more here.
Keywords: use adenoviral; gene therapy; adenoviral vectors; gene ... See more keywords
A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection
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DOI: 10.3389/fimmu.2018.03175
Abstract: Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming… read more here.
Keywords: hcv; adenoviral vectors; hiv hcv; mva ... See more keywords
Role of Adenoviruses in Cancer Therapy
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DOI: 10.3389/fonc.2022.772659
Abstract: Cancer is one of the leading causes of death in the world, which is the second after heart diseases. Adenoviruses (Ads) have become the promise of new therapeutic strategy for cancer treatment. The objective of… read more here.
Keywords: adenoviral vectors; cancer therapy; treatment; tumor ... See more keywords
Expanding the Spectrum of Adenoviral Vectors for Cancer Therapy
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DOI: 10.3390/cancers12051139
Abstract: Adenoviral vectors (AdVs) have attracted much attention in the fields of vaccine development and treatment for diseases such as genetic disorders and cancer. In this review, we discuss the utility of AdVs in cancer therapies.… read more here.
Keywords: vectors cancer; adenoviral vectors; cancer treatment; cancer ... See more keywords
Adenovirus as a Vector and Oncolytic Virus
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DOI: 10.3390/cimb45060307
Abstract: Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and… read more here.
Keywords: oncolytic virus; adenoviral vectors; vector oncolytic; virus ... See more keywords