Adenovirus vector and mRNA vaccines: Mechanisms regulating their immunogenicity
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250022
Abstract: Abstract Replication‐incompetent adenovirus (Ad) vector and mRNA‐lipid nanoparticle (LNP) constructs represent two modular vaccine platforms that have attracted substantial interest over the past two decades. Due to the COVID‐19 pandemic and the rapid development of… read more here.
Keywords: vector mrna; mrna vaccines; adenovirus vector;
Adenovirus vector expressing keratinocyte growth factor using CAG promoter impairs pulmonary function of mice with elastase‐induced emphysema
Sign Up to like & getrecommendations! Published in 2017 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12492
Abstract: Pulmonary emphysema impairs quality of life and increases mortality. It has previously been shown that administration of adenovirus vector expressing murine keratinocyte growth factor (KGF) before elastase instillation prevents pulmonary emphysema in mice. We therefore… read more here.
Keywords: vector; elastase; pulmonary function; adenovirus vector ... See more keywords
Adenovirus vector encoding TPPII ignites HBV‐specific CTL response by activating autophagy in CD8+ T cell
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13638
Abstract: Early studies have shown that autophagy and TPPII are associated with HBV infection. In this study, adenovirus vector containing TPPII was constructed to immunize HBV transgenic mice in vivo to explore the potential mechanism of… read more here.
Keywords: microscopy; autophagy cd8; adenovirus vector; tppii ... See more keywords
A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008459
Abstract: Rabies, caused by RNA viruses in the Genus Lyssavirus, is the most fatal of all infectious diseases. This neglected zoonosis remains a major public health problem in developing countries, causing the death of an estimated… read more here.
Keywords: chimpanzee adenovirus; generation vaccine; human rabies; adenovirus vector ... See more keywords
Adenovirus Vector With ADP Gene Induces Cytopathic Effects in HEK293 Cells Without Significant Elevation of Virus Titers
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15648
Abstract: Background/Aim: Efficient production of adenovirus vectors is crucial for their clinical use. Adenovirus death protein (ADP), which is encoded in the E3 region of the adenovirus genome, is involved in host-cell lysis and the subsequent… read more here.
Keywords: adp gene; adenovirus vector; gene; hek293 cells ... See more keywords
Restricting use of adenovirus vector-based COVID vaccines could endanger public and global health
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.985382
Abstract: COPYRIGHT © 2022 Ertl, Currie and Luber. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided… read more here.
Keywords: vector based; use adenovirus; restricting use; based covid ... See more keywords
Adenovirus as a Vector and Oncolytic Virus
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45060307
Abstract: Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and… read more here.
Keywords: oncolytic virus; adenoviral vectors; vector oncolytic; virus ... See more keywords
The Adenovirus Vector Platform: Novel Insights into Rational Vector Design and Lessons Learned from the COVID-19 Vaccine
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15010204
Abstract: The adenovirus vector platform remains one of the most efficient toolboxes for generation of transfer vehicles used in gene therapy and virotherapy to treat tumors, as well as vaccines to protect from infectious diseases. The… read more here.
Keywords: vaccine; vector platform; vector; adenovirus vector ... See more keywords