Role of pituitary adenylate cyclase‐activating polypeptide in modulating hypothalamic‐pituitary system
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12094
Abstract: Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a multifunctional peptide that is isolated and identified from the ovine hypothalamus, whose effects and mechanisms have been elucidated in numerous studies. The PACAP and its receptor are widely… read more here.
Keywords: activating polypeptide; cyclase activating; pituitary adenylate; adenylate cyclase ... See more keywords
A Bacterial Adenylate Cyclase-Based Two-Hybrid System Compatible with Gateway® Cloning.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7871-7_6
Abstract: The bacterial adenylate cyclase two-hybrid system (BACTH) is a genetic approach used to test protein interactions in vivo in E. coli. This system takes advantage of the two catalytic domains of Bordetella pertussis adenylate cyclase… read more here.
Keywords: hybrid system; system; two hybrid; adenylate cyclase ... See more keywords
Examination of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Potential Biomarker in Heart Failure Patients
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-1025-7
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated… read more here.
Keywords: heart; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Association of adenylate cyclase-2 gene polymorphism with bipolar disorder.
Sign Up to like & getrecommendations! Published in 2020 at "Asian journal of psychiatry"
DOI: 10.1016/j.ajp.2020.102150
Abstract: The pathogenesis of the Bipolar Disorder(BPD) is still unclear. Some studies suggest that abnormal signal transduction in specific pathways may play an important role in the pathogenesis of BPD (Sui et al., 2015). Adenylate cyclase… read more here.
Keywords: cyclase gene; gene; bipolar disorder; adenylate cyclase ... See more keywords
Pleiotropic pituitary adenylate cyclase-activating polypeptide (PACAP): Novel insights into the role of PACAP in eating and drug intake
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DOI: 10.1016/j.brainres.2019.146626
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) was discovered thirty years ago, but its role in eating and drug use disorders has only recently begun to be investigated. The present review develops the hypothesis that, although PACAP… read more here.
Keywords: intake; pacap; pituitary adenylate; adenylate cyclase ... See more keywords
Mechanisms for pituitary adenylate cyclase-activating polypeptide-induced increase in excitability in guinea-pig and mouse adrenal medullary cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172956
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on adrenal medullary (AM) cells as a neurotransmitter of the sympathetic preganglionic nerve. In guinea-pig AM cells, PACAP induces little catecholamine secretion, but enhances secretion evoked by stimulants, whereas… read more here.
Keywords: guinea; guinea pig; pituitary adenylate; adenylate cyclase ... See more keywords
Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents
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DOI: 10.1016/j.neuro.2018.03.010
Abstract: HighlightsPACAP has very potent neuroprotective actions against different neurotoxic agents.We give a summary of the neuroprotective effects against the most commonly used neurotoxic agents, such as 6‐OHDA, MPTP, glutamate and some less well‐known neurotoxic compounds.… read more here.
Keywords: cyclase activating; neuroprotective effects; neurotoxic agents; pituitary adenylate ... See more keywords
Bombesin, endothelin, neurotensin and pituitary adenylate cyclase activating polypeptide cause tyrosine phosphorylation of receptor tyrosine kinases
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DOI: 10.1016/j.peptides.2020.170480
Abstract: Numerous peptides including bombesin (BB), endothelin (ET), neurotensin (NTS) and pituitary adenylate cyclase-activating polypeptide (PACAP) are growth factors for lung cancer cells. The peptides bind to G protein-coupled receptors (GPCRs) resulting in elevated cAMP and/or… read more here.
Keywords: tyrosine; pituitary adenylate; adenylate cyclase; bombesin endothelin ... See more keywords
Multiple nickel‐sensitive targets elicit cardiac arrhythmia in isolated mouse hearts after pituitary adenylate cyclase‐activating polypeptide‐mediated chronotropy
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2016.12.025
Abstract: Graphical abstract Figure. No Caption available. Abstract The pituitary adenylate cyclase‐activating polypeptide (PACAP)‐27 modulates various biological processes, from the cellular level to function specification. However, the cardiac actions of this neuropeptide are still under intense… read more here.
Keywords: cyclase activating; bpm; pacap; pituitary adenylate ... See more keywords
Comparative effects of sub-stimulating concentrations of non-human versus human Luteinizing Hormones (LH) or chorionic gonadotropins (CG) on adenylate cyclase activation by forskolin in MLTC cells.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.01.018
Abstract: We have compared various Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG) preparations from non-human and human species in their ability to synergize with 10 µM forskolin (FSK) for cyclic AMP intracellular accumulation, in MLTC cells. LH… read more here.
Keywords: mltc cells; non human; adenylate cyclase; sub stimulating ... See more keywords
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01396
Abstract: Inhibition of the pituitary adenylate cyclase 1 receptor (PAC1R) is a novel mechanism that could be used for abortive treatment of acute migraine. Our research began with comparative analysis of known PAC1R ligand scaffolds, PACAP38… read more here.
Keywords: induced increase; maxadilan; cyclase receptor; pituitary adenylate ... See more keywords