Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis
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DOI: 10.1002/cmdc.201800332
Abstract: A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared. Five compounds were found to be non‐cytotoxic and selective inhibitors of Bordetella pertussis adenylate cyclase toxin (ACT) in J774A.1 macrophage cell‐based assays.… read more here.
Keywords: potent selective; adenylate cyclases; bacillus anthracis; bordetella pertussis ... See more keywords
Gsα stimulation of mammalian adenylate cyclases regulated by their hexahelical membrane anchors.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109538
Abstract: Mammalian adenylate cyclases (ACs) are pseudoheterodimers with dissimilar hexahelical membrane-anchors, isoform-specifically conserved for more than half a billion years. We exchanged both membrane anchors of the AC isoform 2 by the quorum-sensing receptor from Vibrio… read more here.
Keywords: adenylate cyclases; hexahelical membrane; membrane anchors; mammalian adenylate ... See more keywords
Roles of Adenylate Cyclases in Ciliary Responses of Paramecium to Mechanical Stimulation
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DOI: 10.1111/jeu.12800
Abstract: Paramecium shows rapid forward swimming due to increased beat frequency of cilia in normal (forward swimming) direction in response to various kinds of stimuli applied to the cell surface that cause K+‐outflow accompanied by a… read more here.
Keywords: hyperpolarization; adenylate cyclases; acceleration; mechanical stimulation ... See more keywords
Functional Crypto-Adenylate Cyclases Operate in Complex Plant Proteins
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DOI: 10.3389/fpls.2021.711749
Abstract: Adenylyl cyclases (ACs) and their catalytic product cAMP are regulatory components of many plant responses. Here, we show that an amino acid search motif based on annotated adenylate cyclases (ACs) identifies 12 unique Arabidopsis thaliana… read more here.
Keywords: plant; adenylate cyclases; complex plant; crypto ... See more keywords
Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune Response
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DOI: 10.3390/pathogens7020048
Abstract: Trypanosoma brucei, etiological agent of Sleeping Sickness in Africa, is the prototype of African trypanosomes, protozoan extracellular flagellate parasites transmitted by saliva (Salivaria). In these parasites the molecular controls of the cell cycle and environmental… read more here.
Keywords: camp; response; adenylate cyclases; trypanosoma brucei ... See more keywords