Structural Dynamics Support Electrostatic Interactions in the Active Site of Adenylate Kinase
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200097
Abstract: Electrostatic preorganization as well as structural and dynamic heterogeneity are often used to rationalize the remarkable catalytic efficiency of enzymes. However, they are often presented as incompatible because the generation of permanent electrostatic effects implies… read more here.
Keywords: electrostatic interactions; active site; site adenylate; adenylate kinase ... See more keywords
Adenylate kinase 2 is a biomarker related to the prognosis of glioma and the immune microenvironment.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24892
Abstract: BACKGROUND Among the brain and the other central nervous system, gliomas are the most prevalent malignant primary tumors. Adenylate kinase 2 (AK2) is generally thought to be crucial for energy metabolism and signal transduction. Several… read more here.
Keywords: immune microenvironment; expression; glioma; ak2 expression ... See more keywords
Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology Research"
DOI: 10.1007/s00436-017-5441-y
Abstract: Highly effective and safe prophylactic vaccines are urgently needed to sustainably control schistosomiasis, one of the most serious endemic zoonoses in China. In this study, we characterized adenylate kinase 1 from Schistosoma japonicum (SjAK1), a… read more here.
Keywords: schistosoma japonicum; adenylate kinase; schistosoma; japonicum infection ... See more keywords
Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-019-00576-5
Abstract: Bladder cancer is the second most common urological cancer worldwide with low early diagnosis and high mortality. Since the time of diagnosis directly affects survival rate, early detection and precise biomarkers of bladder cancer are… read more here.
Keywords: bladder cancer; invasion; proliferation; adenylate kinase ... See more keywords
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15308
Abstract: Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for colorectal cancer (CRC) patients with poor prognosis and relapse. However, the context-dependent metabolic traits of CRCSCs remain poorly… read more here.
Keywords: adenylate kinase; cancer stem; colorectal cancer; stem cells ... See more keywords
Water content, adenylate kinase, and mitochondria drive adenylate balance in dehydrating and imbibing seeds
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erx182
Abstract: AMP accumulation in dry seeds, which powers the rapid resumption of energy flow during imbibition, is driven by dehydration through the interplay between ATP demand, adenylate kinase, and oxidative phosphorylation. read more here.
Keywords: kinase mitochondria; adenylate kinase; water content; content adenylate ... See more keywords
Low adenylate kinase 5 expression is predictive of poor prognosis and promotes tumour growth by regulating the cell‐cycle pathway
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13680
Abstract: Colon adenocarcinoma (COAD) is one of the most common malignant tumours of the digestive system. Specific molecular markers play an important role in COAD diagnosis and therapy. Adenylate kinase 5 (AK5) is an enzyme that… read more here.
Keywords: ak5 expression; regulating cell; coad; cell cycle ... See more keywords
Leishmania major adenylate kinase immunization offers partial protection to a susceptible host
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DOI: 10.1111/pim.12688
Abstract: Leishmania major causes mild‐to‐severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug‐resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we… read more here.
Keywords: protection; immunization; leishmania major; major adenylate ... See more keywords
Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.19300
Abstract: Background: We explored the mechanism of maladaptive right ventricular (RV) remodeling in Fischer compared with Sprague-Dawley (SD) rats exposed to pressure overload. Methods: Pulmonary hypertension was induced by injection of the VEGFR antagonist, SU5416, followed… read more here.
Keywords: pressure overload; adenylate kinase; right ventricular; fischer rats ... See more keywords
Characteristics in limbic encephalitis with anti–adenylate kinase 5 autoantibodies
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DOI: 10.1212/wnl.0000000000003586
Abstract: Objective: To report 10 patients with limbic encephalitis (LE) and adenylate kinase 5 autoantibodies (AK5-Abs). Methods: We conducted a retrospective study in a cohort of 50 patients with LE with uncharacterized autoantibodies and identified a… read more here.
Keywords: kinase autoantibodies; adenylate kinase; limbic encephalitis; anterograde amnesia ... See more keywords
Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.630318
Abstract: Macrophages comprise the front line of defense against various pathogens. Classically activated macrophages (M1), induced by IFN-γ and LPS, highly express inflammatory cytokines and contribute to inflammatory processes. By contrast, alternatively activated macrophages (M2) are… read more here.
Keywords: adenylate kinase; hif1; expression; expression inflammation ... See more keywords