Biochemical, thermodynamic and structural studies of recombinant homotetrameric adenylosuccinate lyase from Leishmania braziliensis
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DOI: 10.1039/c7ra10526f
Abstract: Adenylosuccinate lyase (ASL) is involved in both de novo and salvage pathways of purine biosynthesis. ASL belongs to the argininosuccinate lyase/fumarase C superfamily of enzymes which share a general acid–base catalytic mechanism with β-elimination of… read more here.
Keywords: state; leishmania braziliensis; lbasl; adenylosuccinate lyase ... See more keywords
Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum Adenylosuccinate Lyase Receptor
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DOI: 10.1177/1177932219865533
Abstract: Plasmodium falciparum adenylosuccinate lyase (PfADSL) is an important enzyme in purine metabolism. Although several benzimidazole derivatives have been commercially developed into drugs, the template design as inhibitor against PfADSL has not been fully explored. This… read more here.
Keywords: benzo imidazol; plasmodium falciparum; imidazol methyl; adenylosuccinate lyase ... See more keywords