Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03152-y
Abstract: The downregulation of AMP-activated protein kinase (AMPK) activity contributes to numerous pathologies. Recent reports suggest that the elevation of cellular cAMP promotes AMPK activity. However, the source of the cAMP pool that controls AMPK activity… read more here.
Keywords: adenylyl cyclase; ampk activity; activity; biology ... See more keywords
Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.11.012
Abstract: OBJECTIVE This study aimed to investigate the antinociceptive effects of the selective adenylyl cyclase type 1 (AC1) inhibitor ST034307 on tooth movement nociception through orofacial nociceptive behavior tests and molecular examination. METHODS We placed fixed… read more here.
Keywords: movement; nociception; adenylyl cyclase; tooth movement ... See more keywords
Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109635
Abstract: Glucose-stimulated insulin secretion from pancreatic β cells is mediated by Ca2+ influx and amplified by stimulation of GLP-1-receptors through cAMP-based signaling pathways. Interestingly, it has been found that glucose-induced Ca2+ signals can induce concurrent adenylyl… read more here.
Keywords: protein; insulin; adenylyl cyclase; insulin secretion ... See more keywords
Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.11.011
Abstract: Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1)… read more here.
Keywords: adenylyl cyclase; tctex augments; protein coupled; pthr ... See more keywords
Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.049
Abstract: cAMP (Cyclic Adenosine monophosphate), one of the most highly studied second messengers, is regulated by a family of adenylyl cyclase (AC) enzymes. Type 3 adenylyl cyclase (abbreviated as AC3), a subtype of adenylyl cyclase, is… read more here.
Keywords: adenylyl cyclase; type adenylyl; root ganglion; dorsal root ... See more keywords
Light-Induced Change of Arginine Conformation Modulates the Rate of Adenosine Triphosphate to Cyclic Adenosine Monophosphate Conversion in the Optogenetic System Containing Photoactivated Adenylyl Cyclase
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c01308
Abstract: We report the first computational characterization of an optogenetic system composed of two photosensing BLUF (blue light sensor using flavin adenine dinucleotide) domains and two catalytic adenylyl cyclase (AC) domains. Conversion of adenosine triphosphate (ATP)… read more here.
Keywords: optogenetic system; system; adenylyl cyclase; conversion ... See more keywords
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00575
Abstract: The hydrogen bonding network that surrounds the flavin in blue light using flavin adenine dinucleotide (BLUF) photoreceptors plays a crucial role in sensing and communicating the changes in the electronic structure of the flavin to… read more here.
Keywords: spectroscopy; photoactivation; adenylyl cyclase; unnatural amino ... See more keywords
Structural basis of adenylyl cyclase 9 activation
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28685-y
Abstract: Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein Gαs subunit and is autoinhibited by the AC9 C-terminus.… read more here.
Keywords: cyclase; mant gtp; activation; binding site ... See more keywords
Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216599120
Abstract: Nonimage-forming vision in mammals is mediated primarily by melanopsin (OPN4)-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). In mouse M1-ipRGCs, melanopsin predominantly activates, via Gαq,11,14, phospholipase C-β4 to open transient receptor 6 (TRPC6) and TRPC7 channels.… read more here.
Keywords: adenylyl cyclase; cross motif; phototransduction; intrinsically photosensitive ... See more keywords
Oscillation in expression of Adenylyl Cyclase isoforms: new insight to regulation of molecular clock
Sign Up to like & getrecommendations! Published in 2017 at "Biological Rhythm Research"
DOI: 10.1080/09291016.2016.1234756
Abstract: Abstract Background: Mammalian cells contain a cell-autonomous circadian clock that couples endogenous rhythms with changes of cellular environment. Some recent reports have been shown that circadian clock regulates glucose homeostasis; but, their molecular basis is… read more here.
Keywords: adenylyl cyclase; expression; molecular clock; clock ... See more keywords
Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13754
Abstract: Recurrence rates of both lentigo maligna (LM) and lentigo maligna melanoma (LMM) following conventional surgery are usually relatively high. We aimed to assess the frequencies of melanocytes in tumour‐free margins around LM/LMM using soluble adenylyl… read more here.
Keywords: lentigo maligna; around lmm; adenylyl cyclase; soluble adenylyl ... See more keywords