ADH5/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications
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DOI: 10.1038/s41375-025-02687-3
Abstract: Normal hematopoietic stem and progenitor cells (HSPCs) are exposed to physiological levels of formaldehyde but occasionally may be challenged by high levels of formaldehyde generated by endogenous and exogenous sources. In addition, leukemia cells stressed… read more here.
Keywords: dna polymerase; adh5 aldh2; pol; polymerase theta ... See more keywords