Stiffening Matrix Induces Age‐Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201483
Abstract: Aging is a major risk factor in microvascular dysfunction and disease development, but the underlying mechanism remains largely unknown. As a result, age‐mediated changes in the mechanical properties of tissue collagen have gained interest as… read more here.
Keywords: cell; matrix; age; contractility ... See more keywords
Exploiting the Gastric Epithelial Barrier: Helicobacter pylori's Attack on Tight and Adherens Junctions.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/978-3-319-50520-6_9
Abstract: Highly organized intercellular tight and adherens junctions are crucial structural components for establishing and maintenance of epithelial barrier functions, which control the microbiota and protect against intruding pathogens in humans. Alterations in these complexes represent… read more here.
Keywords: gastric epithelial; adherens junctions; tight adherens; epithelial barrier ... See more keywords
Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1599-x
Abstract: Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by… read more here.
Keywords: limiting membrane; adherens junctions; outer limiting; s1p ... See more keywords
TM4SF19 aggravates LPS-induced attenuation of vascular endothelial cell adherens junctions by suppressing VE-cadherin expression.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.08.078
Abstract: Atherosclerosis is a chronic vascular inflammatory disease that initially starts from an arterial intima lesion and endothelial barrier dysfunction. The purpose of this study was to investigate the role of TM4SF19, a recently identified member… read more here.
Keywords: cadherin expression; endothelial cell; adherens junctions; cell adherens ... See more keywords
Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.02.020
Abstract: Vinculin, a mechanotransducer associated with both adherens junctions (AJs) and focal adhesions (FAs), plays a central role in force transmission through cell-cell and cell-substratum contacts. We generated the conditional knockout (cKO) of vinculin in murine… read more here.
Keywords: vinculin; quiescence; hair; adherens junctions ... See more keywords
Nectin stabilization at adherens junctions is counteracted by Rab5a-dependent endocytosis.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2021.151184
Abstract: Cell-cell junctions undergo constant remodeling, which is crucial for the control of vascular integrity. Indeed, transport of junctional components such as cadherins is understood in increasing depth. However, little is known about the respective pathways… read more here.
Keywords: stabilization; cell; adherens junctions; endocytosis nectin ... See more keywords
EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2018.12.017
Abstract: Summary The cochlear sensory epithelium contains a functionally important triangular fluid-filled space between adjacent pillar cells referred to as the tunnel of Corti. However, the molecular mechanisms leading to local cell-cell separation during development remain… read more here.
Keywords: epha4 adam10; adherens junctions; cochlear sensory; sensory epithelium ... See more keywords
Critical roles of adherens junctions in diseases of the oral mucosa
Sign Up to like & getrecommendations! Published in 2022 at "Tissue Barriers"
DOI: 10.1080/21688370.2022.2084320
Abstract: ABSTRACT The oral cavity is directly exposed to a variety of environmental stimuli and contains a diverse microbiome that continuously interacts with the oral epithelium. Therefore, establishment and maintenance of the barrier function of the… read more here.
Keywords: roles adherens; critical roles; oral mucosa; junctions diseases ... See more keywords
α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0071
Abstract: Vinculin is a protein found in both focal adhesions (FAs) and adherens junctions (AJs) which regulates actin connectivity to these structures. Many studies have demonstrated that mechanical perturbations of cells result in enhanced recruitment of… read more here.
Keywords: vinculin; recruitment; vinculin recruitment; focal adhesions ... See more keywords
Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a028738
Abstract: The cadherin-catenin adhesion complex is the key component of the intercellular adherens junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring… read more here.
Keywords: cytoskeleton; integration cadherin; adherens junctions; cadherin adhesion ... See more keywords
Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a029322
Abstract: Endothelial cell-cell adherens junctions (AJs) supervise fundamental vascular functions, such as the control of permeability and transmigration of circulating leukocytes, and the maintenance of existing vessels and formation of new ones. These processes are often… read more here.
Keywords: vascular endothelial; adherens junctions; disease; cadherin endothelial ... See more keywords