GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin‐Associated Ataxia and Neuropathy
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13036
Abstract: To date, 10 patients with GTPase Regulator Associated with Focal Adhesion Kinase 1/Rho GTPase Activating Protein 26‐Immunoglobulin (GRAF1/ARHGAP26‐IgG) associated neurological disorders have been described, most with ataxia. read more here.
Keywords: focal adhesion; adhesion kinase; gtpase regulator; associated focal ... See more keywords
Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.06.012
Abstract: Mesenchymal stromal cells (MSCs) have tremendous potential for use in regenerative medicine due to their multipotency and immune cell regulatory functions. Biomimetic physical forces have been shown to direct differentiation and maturation of MSCs in… read more here.
Keywords: focal adhesion; mesenchymal stromal; adhesion kinase; stromal cells ... See more keywords
Characterization of in vitro metabolism of focal adhesion kinase inhibitors by LC/MS/MS
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.02.028
Abstract: HighlightsThe in vitro metabolites of FAK inhibitors were analyzed by LC/MS/MS.The structures and fragmentation patterns were characterized.Typical metabolic pathways include hydroxylation, dehydrogenation and N‐dealkylation. ABSTRACT Focal adhesion kinase (FAK), a non‐receptor tyrosine kinase, is critically… read more here.
Keywords: focal adhesion; hydroxylation; metabolism; adhesion kinase ... See more keywords
Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00459
Abstract: Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-d]pyrimidine derivatives. An intensive structure-activity relationship (SAR) study led to the identification of… read more here.
Keywords: focal adhesion; adhesion kinase; kinase; pyrimidine derivatives ... See more keywords
Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00250
Abstract: Focal Adhesion Kinase signaling pathway and its functions have been involved in the development and aggressiveness of tumor malignancy, it then presents a promising cancer therapeutic target. Several reversible FAK inhibitors have been developed and… read more here.
Keywords: focal adhesion; inhibitor; adhesion kinase; kinase ... See more keywords
Molecular Docking, Molecular Dynamics Simulations, and Free Energy Calculation Insights into the Binding Mechanism between VS-4718 and Focal Adhesion Kinase
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03951
Abstract: Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that plays an important role in many carcinomas. Thus, the targeting of FAK by small molecules is considered to be promising for cancer therapy.… read more here.
Keywords: molecular docking; fak; kinase; adhesion kinase ... See more keywords
Identification of new binding proteins of focal adhesion kinase using immunoprecipitation and mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49145-6
Abstract: Focal adhesion kinase (FAK) is a 125 kDa protein recruited as a participant in focal adhesion dynamics and serves as a signaling scaffold for the assembly and subsequent maturation of focal contact. Identification of new FAK… read more here.
Keywords: focal adhesion; identification new; binding proteins; adhesion kinase ... See more keywords
Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220162
Abstract: The dense desmoplastic and fibrotic stroma is a characteristic feature of pancreatic ductal adenocarcinoma (PDAC), regulating disease progression, metastasis and response to treatment. Reciprocal interactions between the tumour and stroma are mediated by bidirectional integrin-mediated… read more here.
Keywords: adhesion kinase; focal adhesion; chemotherapy; pdac ... See more keywords
Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low–molecular weight protein tyrosine phosphatase
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-10-0716
Abstract: Osteopontin (OPN), a major marker of osteogenic differentiation, suppresses osteoblast responses to mechanical stress and cytokines, including HGF and PDGF. These OPN-induced effects are mediated through focal adhesion kinase inactivation by the induction of low–molecular… read more here.
Keywords: low molecular; focal adhesion; weight protein; adhesion kinase ... See more keywords
A study of the focal adhesion kinase inhibitor GSK2256098 in patients with recurrent glioblastoma with evaluation of tumor penetration of [11C]GSK2256098
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy078
Abstract: Background GSK2256098 is a novel oral focal adhesion kinase (FAK) inhibitor. Preclinical studies demonstrate growth inhibition in glioblastoma cell lines. However, rodent studies indicate limited blood-brain barrier (BBB) penetration. In this expansion cohort within a… read more here.
Keywords: focal adhesion; adhesion kinase; recurrent glioblastoma; gsk2256098 ... See more keywords
Fibrinogen activates focal adhesion kinase (FAK) promoting colorectal adenocarcinoma growth
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DOI: 10.1111/jth.15440
Abstract: We previously showed that fibrinogen is a major determinant of the growth of a murine model of colorectal cancer (CRC). read more here.
Keywords: focal adhesion; adhesion kinase; activates focal; kinase fak ... See more keywords