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Published in 2020 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-020-09717-w
Abstract: ASP8232 is a novel inhibitor of vascular adhesion protein-1 that was under evaluation for reducing residual albuminuria in patients with diabetic kidney disease. To characterize the pharmacokinetics (PK) of ASP8232 and its effect on vascular…
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Keywords:
vascular adhesion;
adhesion protein;
drug;
target ... See more keywords
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Published in 2018 at "Journal of Equine Veterinary Science"
DOI: 10.1016/j.jevs.2018.08.010
Abstract: Abstract Equine degenerative myeloencephalopathy (EDM), a neurological disease of young horses, causes progressive development of symmetric ataxia predominantly in the pelvic limbs. Equine degenerative myeloencephalopathy is likely inherited and with no known treatment affected horses…
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Keywords:
protein coupled;
adhesion protein;
coupled receptor;
degenerative myeloencephalopathy ... See more keywords
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Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/s41573-019-0039-y
Abstract: Adhesion G protein-coupled receptors (aGPCRs) — one of the five main families in the GPCR superfamily — have several atypical characteristics, including large, multi-domain N termini and a highly conserved region that can be autoproteolytically…
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Keywords:
drug;
adhesion protein;
protein coupled;
coupled receptors ... See more keywords
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Published in 2022 at "Physiological reviews"
DOI: 10.1152/physrev.00027.2021
Abstract: Adhesion G protein-coupled receptors (AGPCRs) are a family of thirty-three receptors in humans exhibiting a conserved general structure but diverse expression patterns and physiological functions. The large N-termini characteristic of AGPCRs confer unique properties to…
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Keywords:
adhesion;
adhesion protein;
physiology;
coupled receptors ... See more keywords
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Published in 2020 at "Molecular Medicine"
DOI: 10.1186/s10020-020-00169-z
Abstract: Fibulins are a family of secreted glycoproteins, which play an important role in regulating multiple cellular functions such as adhesion, growth, motility, and survival. Fibulin7 (Fbln7) is expressed in developing odontoblasts, in the giant trophoblast…
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Keywords:
adhesion;
adhesion protein;
fibulin7;
role ... See more keywords
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Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.873278
Abstract: The adhesion G protein-coupled receptor (aGPCR) GPR126/ADGRG6 plays an important role in several physiological functions, such as myelination or peripheral nerve repair. This renders the receptor an attractive pharmacological target. GPR126 is a mechano-sensor that…
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Keywords:
coupled receptor;
adhesion protein;
gpr126;
gpr126 adgrg6 ... See more keywords
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Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01731
Abstract: Cell migration and adhesion are critical for immune system function and involve many proteins, which must be continuously transported and recycled in the cell. Recycling of adhesion molecules requires the participation of several proteins, including…
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Keywords:
cell migration;
adhesion;
adhesion protein;
lipid rafts ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065499
Abstract: Disorders of the immune system, including immunodeficiency, immuno-malignancy, and (auto)inflammatory, autoimmune, and allergic diseases, have a great impact on a host’s health. Cellular communication mediated through cell surface receptors, among different cell types and between…
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Keywords:
role adhesion;
cell;
protein coupled;
adhesion protein ... See more keywords