Adipocyte‐Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203357
Abstract: Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear. Ferroptosis is a form of nonapoptotic cell death characterized by lipid reactive oxygen species (ROS)… read more here.
Keywords: mttp; derived exosomal; adipocyte derived; colorectal cancer ... See more keywords
The impact of obesity on adipocyte-derived extracellular vesicles
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03973-w
Abstract: Recently, the emerging roles of adipocyte-derived extracellular vesicles (EVs) linking obesity and its comorbidities have been recognized. In obese subjects, adipocytes are having hypertrophic growth and are under stressed. The dysfunction adipocytes dysregulate the assembly… read more here.
Keywords: extracellular vesicles; impact obesity; adipocyte derived; derived extracellular ... See more keywords
Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone–fat balance in osteoporosis by adipocyte-derived exosomes
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2190773
Abstract: Abstract Context Wen-Shen-Tong-Luo-Zhi-Tong (WSTLZT) Decoction is a Chinese prescription with antiosteoporosis effects, especially in patients with abnormal lipid metabolism. Objective To explore the effect and mechanism of WSTLZT on osteoporosis (OP) through adipocyte-derived exosomes. Materials… read more here.
Keywords: wen shen; derived exosomes; adipocyte derived; shen tong ... See more keywords
HIF‐1α downregulation of miR‐433‐3p in adipocyte‐derived exosomes contributes to NPC progression via targeting SCD1
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.14829
Abstract: Resident adipocytes under a hypoxic tumor microenvironment exert an increasingly important role in cell growth, proliferation, and invasion in cancers. However, the communication between adipocytes and cancer cells during nasopharyngeal carcinoma (NPC) progression is poorly… read more here.
Keywords: hif; adipocyte derived; npc progression; expression ... See more keywords
Reduced delivery of epididymal adipocyte‐derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12561
Abstract: Adipocyte‐derived exosomes (Exos) serve as bioinformation‐containing messengers in cell‐to‐cell communications, and numerous reports demonstrate that resistin, an adipokine, is strongly associated with hepatic steatosis and other fatty liver diseases, suggesting that adipose dysfunction‐generated altered pattern… read more here.
Keywords: hepatic steatosis; resistin; adipocyte derived; steatosis ... See more keywords
Abstract P3-01-19: Proteomics-based degradome analysis of mammary tumor adjacent adipocyte reveals adipocyte-derived peptide MASP6 promotes breast cancer cell invasion and migration
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p3-01-19
Abstract: Breast cancer is the most common female malignancy all over the word, at a risen rate of over 1.7 million cases per year globally, where metastasis is the leading cause of death. Accumulating epidemiological evidence… read more here.
Keywords: cancer; adipocyte derived; tumor; breast cancer ... See more keywords
Adipocyte-derived PGE2 is required for intermittent fasting-induced Treg proliferation and improvement of insulin sensitivity.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.153755
Abstract: The intermittent fasting (IF) diet has profound benefits for diabetes prevention. However, the precise mechanisms underlying IF's beneficial effects remain poorly defined. Here, we show that the expression levels of cyclooxygenase-2 (COX-2), an enzyme that… read more here.
Keywords: adipocyte derived; intermittent fasting; insulin; treg proliferation ... See more keywords
Evidence for Adipocyte-Derived Extracellular Vesicles in the Human Circulation
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00266
Abstract: Adipocyte-derived extracellular vesicles (EVs) may serve as novel endocrine mediators of adipose tissue and impact upon vascular health. However, it is unclear whether adipocyte-derived EVs are present in the human circulation. Therefore, the purpose of… read more here.
Keywords: extracellular vesicles; human circulation; adipocyte; adipocyte derived ... See more keywords
Adipocyte-Derived Extracellular Vesicles: State of the Art
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041788
Abstract: White adipose tissue (WAT) is involved in long-term energy storage and represents 10–15% of total body weight in healthy humans. WAT secretes many peptides (adipokines), hormones and steroids involved in its homeostatic role, especially in… read more here.
Keywords: extracellular vesicles; adipocyte derived; derived extracellular; vesicles state ... See more keywords
Adipocyte-derived extracellular vesicles sustain mitochondrial metabolism in breast cancer cells: New insights into the cross-talk between cancer cells and the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Oncology"
DOI: 10.3892/ijo.2025.5806
Abstract: Adipocytes represent the most prominent component of breast tissue stroma and are recognized as significant contributors to the observed association between obesity and breast cancer (BC). It has been widely reported that dysfunctional adipose tissue… read more here.
Keywords: derived evs; cancer; cancer cells; breast ... See more keywords
Unlocking the paracrine crosstalk: adipocyte-derived factors affect carbonic anhydrase IX expression in colon and breast cancer cells.
Sign Up to like & getrecommendations! Published in 2024 at "Neoplasma"
DOI: 10.4149/neo_2024_240321n127
Abstract: Obesity is a major public health concern because it increases the risk of several diseases, including cancer. Crosstalk between obesity and cancer seems to be very complex, and the interaction between adipocytes and cancer cells… read more here.
Keywords: cancer; cancer cells; carbonic anhydrase; colon ... See more keywords