A PPAR-alpha agonist and DPP-4 inhibitor mitigate adipocyte dysfunction in obese mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-21-0084
Abstract: Obesity causes white and brown adipocyte dysfunction, reducing browning and stimulating whitening. Drugs that tackle adipocyte dysfunction through thermogenesis stimulation could be used to treat obesity. This study sought to address whether a combination of… read more here.
Keywords: combination; alpha agonist; dysfunction; adipocyte dysfunction ... See more keywords
Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020740
Abstract: Obesity prevalence is increasing worldwide, leading to cardiometabolic morbidities. Adipocyte dysfunction, impairing white adipose tissue (WAT) expandability and metabolic flexibility, is central in the development of obesity-related metabolic complications. Rare syndromes of lipodystrophy characterized by… read more here.
Keywords: adipose tissue; adipocyte dysfunction; seipin deficiency;