Type I interferon sensing unlocks dormant adipocyte inflammatory potential
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16571-4
Abstract: White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation in disease pathogenesis remain poorly defined. We show that… read more here.
Keywords: type interferon; adipocyte inflammatory; inflammation; interferon ... See more keywords
A role for PFKFB3/iPFK2 in metformin suppression of adipocyte inflammatory responses.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-17-0066
Abstract: Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation. The objective of the study is to examine the direct effect of metformin on adipocyte inflammatory responses and elucidate the underlying mechanisms.… read more here.
Keywords: inflammatory responses; adipocyte inflammatory; metformin; pfkfb3 ipfk2 ... See more keywords